Molecular mechanisms and physiological functions of mitophagy
By Mashun Onishi, Koji Yamano, Miyuki Sato, N. Matsuda, Koji Okamoto. EMBO Journal, 2021
1,187 citations recorded by the source corpus.
Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a fundamental mechanism conserved from yeast to humans that regulates mitochondrial quality and quantity control. Mitophagy is promoted via specific mitochondrial outer membrane receptors, or ubiquitin molecules conjugated to proteins on the mitochondrial surface leading to the formation of autophagosomes surrounding mitochondria. Mitophagy‐mediated elimination of mitochondria plays an important role in many processes including early embryonic development, cell differentiation, inflammation, and apoptosis. Recent advances in analyzing mitophagy in vivo also reveal high rates of steady‐state mitochondrial turnover in diverse cell types, highlighting the intracellular housekeeping role of mitophagy. Defects in mitophagy are associated with various pathological conditions such as neurodegeneration, heart failure, cancer, and aging, further underscoring the biological relevance. Here, we review our current molecular understanding of mitophagy, and its physiological implications, and discuss how multiple mitophagy pathways coordinately modulate mitochondrial fitness and populations.
Subfields: Cell Biology, Epidemiology, Neurology
View Paper: https://www.semanticscholar.org/paper/18b2eaa681a3b000788750967118199194c6b24d
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Citations in the corpus
- The mitophagy pathway and its implications in human diseases (2023, background): “3,4,6 However, few articles summarize how alterations in mitophagy affect disease development, and interventions speci fi cally targeting the regulation of mitophagy are unavailable in clinical trials.”
- Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation (2023, background): “Mitochondrial autophagy, also known as mitophagy, is essential for maintaining mitochondrial and cellular homeostasis [10].”
- Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “Mitophagy, a selective type of autophagy, specifically degrades damaged or redundant mitochondria within the cell.(151) Changes in the expression of mitophagy-related proteins can affect the degradation of damaged mitochondria and are closely related to cellular senescence.”