Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β

By N. Dupont, Shanya Jiang, Manohar Pilli, Wojciech Ornatowski, Dhruva Bhattacharya, V. Deretic. EMBO Journal, 2011

941 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ad704e911aaf5c8083a95bc320d2bdea4fd7e70a

How researchers see this paper

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In Epidemiology

1. V. Deretic
2. L. Galluzzi
3. D. Tang
4. Douglas R. Green
5. R. Kang
6. T. Johansen
7. P. Codogno
8. Michael Lotze

In Molecular Biology

1. D. Tang
2. R. Kang
3. Douglas R. Green
4. L. Galluzzi
5. Guido Kroemer
6. V. Deretic
7. H. J. Zeh
8. P. Boya

Citations in the corpus

• Emerging regulation and functions of autophagy (2013, background): “The Atg machinery has now been shown to participate in the release of cargoes into the extracellular medium, shedding light on the mechanism of a few types of unconventional protein secretion [45] [46] [47] .”
• Molecular definitions of autophagy and related processes (2017, neutral): “…with extracellular functions, potentially cytotoxic protein aggregates, secretory granules, and invading pathogens) (Manjithaya et al , 2010; Dupont et al , 2011; Shravage et al , 2013; Lock et al , 2014; Gerstenmaier et al , 2015; Kimura et al , 2017), which led to the introduction of the…”
• TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation (2012, positive): “In the context of antiinflammatory function, autophagy plays an inhibitory role in inflammasome and IL-1b activation (Dupont et al., 2011; Nakahira et al., 2011; Zhou et al., 2011).”
• Human Monocytes Engage an Alternative Inflammasome Pathway. (2016, neutral): “, 2015) and the autophagy machinery (Dupont et al., 2011).”
• Autophagy-Independent Functions of the Autophagy Machinery (2019, background): “Major cellular functions involving components of the autophagy machinery Functions Protein Autophagic Role References Related to membrane biology Cytokine secretion ATG7 Elongation Henault et al., 2012; Li et al., 2016 ULK1 Initiation Cytokinesis BECN1 Nucleation Thoresen et al., 2010; You et al., 2”
• PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “Interestingly, autophagy not only inhibits IL-1b release by targeting proIL-1b for p62-mediated lysosomal degradation (193, 194) but also promotes IL-1b release by unconventional secretory pathway (195), suggesting a dual roles of autophagy in regulation of IL-1b signaling including inflammasome act”
• Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014, background): “Lack of fever induction may be explained by the fact that IL-18 signals through the MAPK p38 pathway instead of the NF-κB pathway, which is used by IL-1β (54).”