The LIR motif – crucial for selective autophagy

By Å. Birgisdottir, T. Lamark, T. Johansen. Journal of Cell Science, 2013

853 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/3c85675a4df93cc577d5de31a9a154033273dbfd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. V. Deretic
2. T. Lamark
3. T. Johansen
4. R. Yadav
5. H. Chae
6. S. Martens
7. Hyung-Ryong Kim
8. H. Rashid

In Epidemiology

1. V. Deretic
2. T. Lamark
3. T. Johansen
4. R. Yadav
5. H. Chae
6. S. Martens
7. Hyung-Ryong Kim
8. H. Rashid

In Physiology

1. R. Yadav
2. H. Chae
3. T. Johansen
4. Hyung-Ryong Kim
5. H. Rashid
6. V. Deretic
7. T. Lamark

Citations in the corpus

• Autophagy in inflammation, infection, and immunometabolism (2021, background): “) (Birgisdottir et al., 2013; Deretic et al., 2013) which patrol the cytosol accessing diverse targets.”
• Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation (2016, background): “The autophagy receptor and LC3/GAB ARAP interactions bridge the autophagy machinery with cargo, thereby fostering selective engulfment by the autophagosome (Birgisdottir et al., 2013; Stolz et al., 2014).”
• Molecular definitions of autophagy and related processes (2017, neutral): “Atg32 is the main receptor for macroautophagic responses targeting dispensable mitochondria in yeast (Kanki et al , 2009; Okamoto et al , 2009), and BCL2-like 13 (BCL2L13) has been suggested to play analogous functions in mitophagy in mouse and human cells (Murakawa et al , 2015).”
• ER stress: Autophagy induction, inhibition and selection (2015, background): “(reviewed in reference.(171)) Mounting evidence suggests that SQSTM1 and NBR1 can act as universal receptors for almost all types of ubiquitinated cargo.”
• A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress (2020, background): “Selective autophagy receptors interact with ATG8 via conserved motifs called the ATG8 interacting motif (AIM) or LC3-interacting region (LIR) (Birgisdottir et al., 2013).”
• Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors. (2020, background): “Further structure studies using isolated LIR peptides bound to ATG8 proteins or LIR peptides expressed as N-terminal extensions of ATG8 proteins showed that LIRs usually bind as an extended β-sheet to the LDS [22,69,70].”
• Neuronal Cell Death. (2018, neutral): “p62 is a member of a family of adaptor proteins with LC3 interacting region (LIR) motifs that link LC3 or its congeners on autophagosomes to ubiquitylated proteins in the cytoplasm or on organelles destined for autophagic degradation (48).”
• Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “dated or predicted protein-protein, transcription factor-gene and miRNA-mRNA interactions related to autophagy in human.(1479) ARN contains data from 26 resources, including an in-house extensive manual curation, the dataset of the ChIPMS study of Behrends et al.”
• Mechanisms of Selective Autophagy (2016, neutral): “The LIR motif consists of the consensus sequence Θ XX Γ , where Θ is an aromatic residue (W/F/Y) and Γ is hydrophobic (L/I/V), while X is any other residue [82,83].”