Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.

By V. Rogov, V. Dötsch, T. Johansen, V. Kirkin. Molecules and Cells, 2014

959 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Parasitology

View Paper: https://www.semanticscholar.org/paper/815bf25e9bd5b6dde323053580e29efb5c37ea3d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Guido Kroemer
2. Beth Levine
3. L. Galluzzi
4. T. Lamark
5. T. Johansen
6. P. Codogno
7. Eric H. Baehrecke
8. W. Zong

In Epidemiology

1. Guido Kroemer
2. Beth Levine
3. L. Galluzzi
4. Alec C. Kimmelman
5. N. Mizushima
6. T. Johansen
7. T. Lamark
8. P. Codogno

In Parasitology

1. Guido Kroemer
2. L. Galluzzi
3. Beth Levine
4. T. Lamark
5. P. Codogno
6. T. Johansen
7. Eric H. Baehrecke
8. Alec C. Kimmelman

Citations in the corpus

• p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation (2016, neutral): “(xenophagy), surplus endoplasmic reticulum (reticulophagy), ribosomes (ribophagy) and mid-body ring structures [13].”
• Autophagy in malignant transformation and cancer progression (2015, positive): “Several receptors participate in the selective recognition and recruitment of autophagosomal cargoes in the course of targeted autophagic responses (Rogov et al , 2014; Stolz et al , 2014).”
• Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation (2016, background): “A key question arises: why are LC3s mechanistically different from GAB ARAPs? Structurally, LC3s and GAB ARAPs share a ubiquitin-like core but differ substantially at their Nterminal α helices (Rogov et al., 2014).”
• Autophagy mediates degradation of nuclear lamina (2015, positive): “The autophagy protein LC3/Atg8, which is involved in autophagy membrane trafficking and substrate delivery 4–6 , is present in the nucleus and directly interacts with the nuclear lamina protein Lamin B1, and binds to lamin-associated domains (LADs) on chromatin.”
• Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors. (2020, background): “A second function of lipidated ATG8 proteins is the LIR-dependent attachment of SARs (with our without cargo) to the inner (concave) surface of the phagophore [19,20].”
• Molecular definitions of autophagy and related processes (2017, neutral): “In addition, dozens of proteins have been involved in the recognition of macroautophagy substrates (see above) (Rogov et al , 2014; Farre & Subramani, 2016).”