Emerging regulation and functions of autophagy

By P. Boya, F. Reggiori, P. Codogno. Nature Cell Biology, 2013

1,209 citations recorded by the source corpus.

Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses — indicating the novel frontiers lying ahead.

Subfields: Cell Biology, Epidemiology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/d3a56a10e94428c18554a7be3ffbc8a8e72a61b2

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Citations in the corpus

PI(5)P Regulates Autophagosome Biogenesis (2015, background): “…PI(5)P is associated with autophagy effectors that bind PI(3)P d PI(5)P sustains noncanonical autophagy in PI(3)P-depleted cells d PI(5)P is essential for VPS34-independent, glucose- starvation-induced autophagy Vicinanza et al., 2015, Molecular Cell 57, 219–234 January 22, 2015 ª2015 The…”
Autophagy and multidrug resistance in cancer (2017, background): “The major protein degradation systems include the ubiquitin–proteasome pathway (targeting short-lived and misfolded proteins) and the lysosome-autophagy system (targeting long-lived macromolecular complexes and organelles) [1, 2].”
Reactive oxygen species and mitochondria: A nexus of cellular homeostasis (2015, background): “More than 30 autophagy-related proteins have been identified, and their molecular functions are discussed elsewhere [51,52].”
The Roles of Autophagy in Cancer (2018, background): “In animal studies, metabolic stress is observed in autophagy-deficient cells, resulting in impaired cell survival [77].”
Autophagy in malignant transformation and cancer progression (2015, neutral): “A detailed discussion of additional factors that are involved in the control and execution of autophagic responses can be found in Boya et al (2013).”
Apoptosis, autophagy, necroptosis, and cancer metastasis (2015, background): “It is thus critical for cell growth regulation and internal homeostasis [69].”
Molecular definitions of autophagy and related processes (2017, neutral): “Indeed, both autophagy substrates and receptors are subjected to lysosomal degradation, but only the latter function as part of the autophagy apparatus (Boya et al , 2013; Noda & Inagaki, 2015; Zaffagnini & Martens, 2016).”