Autophagy in inflammation, infection, and immunometabolism

By V. Deretic. Immunity, 2021

709 citations recorded by the source corpus.

Summary Autophagy is a quality control, metabolic and innate immunity process. Normative autophagy affects many cell types, including hematopoietic as well as non-hematopoietic, and promotes health in model organisms and humans. When autophagy is perturbed, this has repercussions on diseases with inflammatory components, including infections, autoimmunity and cancer, metabolic disorders, neurodegeneration, and cardiovascular and liver diseases. As a cytoplasmic degradative pathway, autophagy protects from exogenous hazards including infection and from endogenous sources of inflammation including molecular aggregates and damaged organelles. The focus of this review is on the role of autophagy in inflammation, including type I interferon responses and inflammasome outputs, from molecules to immune cells. A special emphasis is given to the intersections of autophagy with innate immunity, immunometabolism, and functions of organelles such as mitochondria and lysosomes that act as innate immunity and immunometabolic signaling platfroms.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5ac605389104e30cfe37af9b4b039f01597734a6

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In Molecular Biology

1. Yan Yu
2. Weitong Gao
3. Yang Zhou
4. Xuepeng Wang

Citations in the corpus

• Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “AUTOPHAGY ANTAGONIZES THE ANTITUMOR IMMUNE RESPONSE Autophagy may enhance or inhibit the growth, development, and functional performance of immune cells, depending on whether they have tumor-promoting or antitumor function.(159,270,271) In addition, autophagy is also involved in antigen-presentation”