Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

By A. Hsu, Coleen T. Murphy, C. Kenyon. Science, 2003

1,535 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7d72e1b8af367198640efb15b1e1a9de65e1fe86

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Citations in the corpus

A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. (2012, neutral): “…is essential for viability in budding yeast, and absence of its ortholog in mice has a range of effects (Christians and Benjamin, 2006), including neurodegeneration and resistance to acquiring cancer (Dai et al., 2007), whereas overexpression leads to increased lifespan in worms (Hsu et al., 2003).”
Some like it hot: the structure and function of small heat-shock proteins (2005, background): “The clinical importance of sHsps is further highlighted by a growing number of fundamental cellular processes in which they have been found to be involved, among them protection against oxidative stress and aging, interference with apoptosis, neurological disorders and neuroprotective effect”
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (2006, positive): “6 (Figure S6), which is thought to contribute to DAF-16-dependent life-span extension (Hsu et al., 2003).”
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. (2007, background): “Intriguingly, in nematodes , HSF1 promotes longevity under stable laboratory conditions (Hsu et al., 2003; Morley and Morimoto, 2004).”
A Heat-Inducible Transcription Factor, HsfA2, Is Required for Extension of Acquired Thermotolerance in Arabidopsis1[W][OA] (2006, background): “For example, Saccharomyces cerevisiae, Drosophila melanogaster, and Caenorhabditis elegans each has a single Hsf gene playing an important biological role in addition to the HSR (Sorger and Pelham, 1988; Wiederrecht et al., 1988; Jedlicka et al., 1997; Hsu et al., 2003).”
Body size, energy metabolism and lifespan (2005, background): “Many of the mutations identified in C. elegans that are linked to lifespan effects include mutations in the insulin and insulin-like growth factor (IGF) signalling pathways (Hsu et al., 2003).”
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. (2003, background): “%) than we observed by initiating RNAi in adults (Hsu et al., 2003).”
The plasticity of aging: insights from long-lived mutants. (2005, background): “The finding that overexIpression of the heat-shock factor HSF-1 extends life nspan in C. elegans (Hsu et al., 2003; Morley and Morilmoto, 2004) provides a possible explanation for this infteresting phenomenon; namely, that stress activates nHSF-1, which, in turn, increases life span by activating…”
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. (2003, background): “How-stress-response genes (McElwee et al., 2003; Murphy ever, with the exception of the nervous system, whichet al., 2003; Yu and Larsen, 2001) that contribute to daf-2 does not show signs of age (Herndon et al. 2002), withinlongevity (Hsu et al., 2003; Murphy et al., 2003).”
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging (2009, methodology): “Animals were stained with rhodamine phalloidin (Molecular Probes) and with either anti-paramyosin [5-23] (57), anti-myosin heavy chain B [28.”
Ageing and vision: structure, stability and function of lens crystallins. (2004, background): “elegans it was shown that lack of sHsps contributes to ageing (Hsu et al., 2003) and therefore the abundance of a-crystallin in lens epithelial cell would be expected to delay ageing of these cells.”
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. (2008, background): “The demonstration that the DAF-16 and HSF1 stress pathways have essential roles in the regulation of proteostasis and life span provides an important insight.”
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. (2008, positive): “HSF-1 and DAF-16 are predicted to bind to some of the same promoters and regulate some pro-longevity target genes together (Hsu et al., 2003).”
The hallmarks of aging. (2013, background): “Moreover, activation of the master regulator of the heat-shock response, the transcription factor HSF-1, increases longevity and thermotolerance in nematodes (Chiang et al., 2012; Hsu et al., 2003), while amyloid-binding components can maintain proteostasis during aging and extend lifespan (Alavez e”