A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.

By Maria K. Lehtinen, Zengqiang Yuan, Peter R. Boag, Yue Yang, J. Villén, Esther B. E. Becker, Sara DiBacco, N. de la Iglesia, Steven P. Gygi, T. Blackwell and 1 more. Cell, 2006

864 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/091415a92b146561aa25996049d018f41f37bcc0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. A. Brunet
2. Hilmar Bading
3. G. Hardingham

In Molecular Biology

1. K. Guan
2. Duojia Pan
3. S. Piccolo
4. M. Cordenonsi
5. Yonggang Zheng
6. S. Dupont
7. Bin Zhao
8. Jixin Dong

In Physiology

1. Dervis A M Salih
2. A. Brunet

Citations in the corpus

• The Hippo Signaling Pathway in Development and Disease (2019, background): “…normal processes, such as energy deficit (DeRan et al., 2014; Mo et al., 2015; Wang et al., 2015b), hypoxia (Ma et al., 2015), oxidative stress (Lehtinen et al., 2006), endoplasmic reticulum stress (Wu et al., 2015), cytokinesis failure (Ganem et al., 2014), osmotic stress (Hong et al., 2017;…”
• Elucidation of a universal size-control mechanism in Drosophila and mammals. (2007, background): “For example, Mst1/2 was reported to phosphorylate histone H2B (Cheung et al., 2003) and FOXO transcription factors (Lehtinen et al., 2006).”
• The biology of YAP/TAZ: hippo signaling and beyond. (2014, background): “In this pathway, the downstream targets of MST1/2 include the stress-induced JNK and p38 kinases, the histones H2B and H2AX, and FOXO transcription factors (35, 113, 202, 229, 248).”
• The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network (2007, background): “Indeed, MST kinases have been shown to respond to various stimuli, from osmotic shock to oxidative stres”
• SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction (2007, background): “…oxidative stressinduced neuronal cell death, while at the whole animal level, C. elegans MST1 ortholog CST-1 promotes longevity of the worm (Lehtinen et al., 2006), suggesting that the beneficial effect of up-regulating FOXO/Daf-16 activity on lifespan extension may be partly due to the…”
• FoxO transcription factors in the maintenance of cellular homeostasis during aging. (2008, background): “Apoptosis Bim Bcl2-interacting mediatior of cell death + ChIP + [15,28,75 ]”
• ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis (2007, background): “activates H 2 O 2 -induced FOXO protective functions, whereas the sterile-like kinase MST1 mediates H 2 O 2 -induced FOXO activation that leads to cell deat”
• Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects (2015, neutral): “…not involve or require cell divisions that might dilute or induce repair of macromolecular damage might contribute to the fact that aging phenotypes present in cultured primary fibroblasts become translated to a neuronal context during iN (Hennekam, 2006; Liu et al., 2013; Toyama and Hetzer, 2013).”
• Hippo signaling in organ size control. (2007, background): “This proapoptotic function appears to involve direct phosphorylation of substrates other than Wts, such as histone H2B (Cheung et al. 2003) or FOXO transcription factors (Lehtinen et al. 2006).”