Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

By Anat Ben-Zvi, E. Miller, Richard I. Morimoto. Proceedings of the National Academy of Sciences of the United States of America, 2009

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Molecular chaperones in protein folding and proteostasis (2011, background): “Thus, the age-related decline in proteostasis and specifically in the inability to upregulate chaperones in response to conformational stresses would trigger disease manifestation and, in turn, accelerate proteostasis collaps”
In vivo aspects of protein folding and quality control (2016, background): “a fully functional PN may buffer the destabilizing effects of SNPs on protein conformation, metastable mutant proteins tend to aggregate when PN capacity is overwhelmed, as occurs progressively during aging (142, 143).”
Cellular strategies for controlling protein aggregation (2010, background): “elegans , the general decline of protein quality control happens at an early stage of adulthood and thus is an early molecular event during cellular ageing in this organis”
Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans (2010, neutral): “elegans [40].”
Pathways of cellular proteostasis in aging and disease (2018, background): “In worms, this decline in PN capacity is tied to development, suggestive of a regulated program of aging (Ben-Zvi et al., 2009; Labbadia and Morimoto, 2015b).”