Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.

By Chengkai Dai, L. Whitesell, A. Rogers, Susan Lindquist. Cell, 2007

859 citations recorded by the source corpus.

Subfields: Aging, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8e6823ac47cd9c472d69ed3311317e0fa0524b23

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Lea Sistonen
2. Richard I. Morimoto
3. Stephen J. Elledge
4. F. Hartl
5. Linda Partridge
6. Luigi Fontana

In Cell Biology

1. Ji Luo
2. Richard I. Morimoto
3. Stephen J. Elledge
4. N. Solimini
5. F. Hartl

In Molecular Biology

1. Lea Sistonen
2. Richard I. Morimoto
3. William A. Freed-Pastor
4. Carol Prives
5. Ji Luo
6. Stephen J. Elledge
7. N. Solimini
8. F. Hartl

Citations in the corpus

• Mutant p53: one name, many proteins. (2012, background): “In fact, deletion of HSF1, a master regulator of the heat-shock response, dramatically impacts tumor formation and overall survival in the mutant p53 knock-in mouse model (Dai et al. 2007), and inhibition of either Hsp90 or HDAC6 is sufficient to destabilize mutant p53 in cancer cell lines and there”
• Targeting the dynamic HSP90 complex in cancer (2010, background): “Recently, HSF1 expression has been shown to be an important facilitator of oncogenesi”
• Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009, positive): “Loss of HSF1 markedly reduces tumorigenesis driven by either p53 or Ras mutations (Dai et al., 2007).”
• Heat shock factors: integrators of cell stress, development and lifespan (2010, result): “Similar results have been obtained in human cancer cells lines, in which HSF1 was depleted using an RNA interference strateg”
• Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. (2008, background): “GENES & DEVELOPMENT 22:1427–1438 © 2008 by Cold Spring Harbor Laboratory Press ISSN 0890-9369/08; www.genesdev.org 1427 location (Hartl and Hayer-Hartl 2002; Deuerling and Bukau 2004; Bukau et al. 2006; Ron and Walter 2007).”
• A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. (2012, neutral): “…is essential for viability in budding yeast, and absence of its ortholog in mice has a range of effects (Christians and Benjamin, 2006), including neurodegeneration and resistance to acquiring cancer (Dai et al., 2007), whereas overexpression leads to increased lifespan in worms (Hsu et al., 2003).”
• HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. (2012, neutral): “Gene Expression Analysis Lentiviral shRNA methods were described previously (Dai et al., 2007).”