Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.

By James F Morley, Richard I. Morimoto. Molecular Biology of the Cell, 2003

782 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/59fb362cef950f1cb97a2b0971b60379972ad61c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Richard I. Morimoto
2. F. Hartl
3. M. Hayer-Hartl
4. Lea Sistonen
5. G. Lithgow
6. Rute Martins
7. W. Link
8. A. Bracher

In Molecular Biology

1. Richard I. Morimoto
2. F. Hartl
3. M. Hayer-Hartl
4. Susan Lindquist
5. L. Whitesell
6. U. Hartl
7. A. Bracher
8. C. Kenyon

In Physiology

1. G. Lithgow
2. Rute Martins
3. W. Link
4. M. Hayer-Hartl
5. C. Kenyon
6. F. Hartl
7. Lea Sistonen
8. Richard I. Morimoto

Citations in the corpus

• The plasticity of aging: insights from long-lived mutants. (2005, background): “Interestingly, in C. elegans, the heat-shock factor HSF-1 also acts in a cell-nonautonomous fashion to extend the life spans of daf-2-pathway mutants (Morley and Morimoto, 2004).”
• Heat shock factors: integrators of cell stress, development and lifespan (2010, background): “Conversely, inhibition of IGF1R signalling results in HSF activation and promotes longevity by maintaining proteostasi”
• Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (2006, result): “This is consistent with recent results showing that global alteration of Ins2- and HSF1-mediated stress-response pathways arrest and reverse onset of aggressive misfolding amyloid diseases in C. elegans (Gidalevitz et al., 2006; Morley and Morimoto, 2004).”
• Long live FOXO: unraveling the role of FOXO proteins in aging and longevity (2015, background): “HSF-1, along with DAF-16, promotes longevity by activating specific longevity genes, including genes that encode small heat-shock proteins (Garigan et al., 2002; Hsu et al., 2003; Walker & Lithgow, 2003; Morley & Morimoto, 2004).”
• Molecular chaperones in protein folding and proteostasis (2011, background): “A plausible explanation for the late onset of these diseases is provided by recent evidence from model organisms that the signalling pathways that regulate proteostasis are integrated with the genetic and epigenetic pathways that control longevit”
• Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. (2007, background): “Intriguingly, in nematodes , HSF1 promotes longevity under stable laboratory conditions (Hsu et al., 2003; Morley and Morimoto, 2004).”
• Converging concepts of protein folding in vitro and in vivo (2009, background): “Recent advances in understanding the genetic programs underlying the aging process indicate that the functional capacity of molecular chaperones and other aspects of protein quality control decrease during agin”
• Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. (2008, background): “elegans accelerated the aggregation of polyQ supporting the proposition that the ILS could coordinately influence aging and protein aggregation through the action of DAF-16 and HSF1 (Hsu et al. 2003; Morley and Morimoto 2004).”