Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.
By Jennifer M. A. Tullet, Maren Hertweck, J. An, J. Baker, Ji Yun Hwang, Shu Liu, Riva de Paula Oliveira, R. Baumeister, T. Blackwell. Cell, 2008
927 citations recorded by the source corpus.
Subfields: Aging, Endocrine and Autonomic Systems, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/50155e57bcf887631dcfaedbce1a9425dee0a41b
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Aging
- Luigi Fontana
- Linda Partridge
- David M. Sabatini
- T. Blackwell
- Catherine Au
- Monica Driscoll
- Brian Onken
- Nir Barzilai
In Endocrine and Autonomic Systems
- Luigi Fontana
- Linda Partridge
- David M. Sabatini
- T. Blackwell
- Catherine Au
- Monica Driscoll
- Brian Onken
In Molecular Biology
- Linda Partridge
- David M. Sabatini
- T. Blackwell
- Luigi Fontana
- M. Laplante
- R. A. Saxton
- Michael N. Hall
- K. Guan
Citations in the corpus
- Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology (2008, background): “Pathways relevant to oxidative stress– related neuronal injuries, such as the p38 mitogen-activated protein kinase and AKT signaling cascades, the ubiquitinproteasome pathway, and the oxidative stress response are also conserved in the worm (Ayyadevara et al., 2005, 2008; Daitoku and Fukamizu, 2007;”
- TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO (2012, background): “DAF-16 and SKN-1 regulate genes that protect against environmental, metabolic, and proteotoxic stress, and promote longevity in various species (Kenyon, 2010; Kwon et al., 2010; Li et al., 2011; Oliveira et al., 2009; Sykiotis and Bohmann, 2010; Tullet et al., 2008).”
- Promoting Health and Longevity through Diet: from Model Organisms to Humans (2015, positive): “Even chronic starvation extends lifespan in C. elegans (Kaeberlein et al., 2006; Lee et al., 2006), through mechanisms that overlap with those mediating the response to IF and that include the combined activity of FOXO, FOXA and AP-1 transcription factors in two parallel starvation–responsive pathwa”
- Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1 (2010, background): “Under oxidative stress and with reduced insulin signaling, SKN-1 accumulates in intestinal nuclei leading to SKN-1 target gene expression [35,69,71].”