Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells.

By H. Yagi, T. Nomura, Kyoko Nakamura, S. Yamazaki, T. Kitawaki, S. Hori, M. Maeda, M. Onodera, T. Uchiyama, S. Fujii and 1 more. International Immunology, 2004

839 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/bea8840cc67b2314037a70e49cbf862a019deeef

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In Immunology

1. Shimon Sakaguchi
2. Alexander Y. Rudensky
3. Ye Zheng
4. K. Wing
5. B. Beutler
6. T. Nomura
7. J. Fontenot
8. M. Ono

Citations in the corpus

• Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. (2006, background): “subsets (22), ‘‘Tregs’’ were defined as lymphocytes that possessed the Regulatory T Cells and Malignant Glioma”
• CD4+T Cells: Differentiation and Functions (2012, background): “Fatal immunopathology followed as a result of FOXP3 deletion/mutation, which resulted in defective and decreased iTreg cells [86, 87].”
• Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. (2006, background): “As is seen in the mouse system, the transduced cells display anergy when stimulated through the TCR and are capable of suppressing responder CD4+ T cells (76, 80, 81).”
• Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease (2006, background): “Importantly, activation of CD25CD4 T cells, Th1 cells, or Th2 cells fails to induce Foxp3 expression, at least within several days of in vitro stimulation, in mice (17, 19, 24).”
• Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self (2005, background): “Although these findings indicate CD25 is a 'rational' molecular marker for natural T reg cells, some T cells in the CD25 − CD45RB lo CD4 + T cell fraction, which represents less than 10% of CD25 − CD4 + T cells in normal naive mice, also have intermediate expression of Foxp3 and show in vitro ”
• FOXP3+ regulatory T cells in the human immune system (2010, background): “Expression of these receptors also correlates with FOXP3 expression in human CD4 + T cell”
• Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans (2006, background): “Our studies demonstrated that retroviral mediated ectopic expression of Foxp3 in CD4CD25 T cells does not result in a strong and stable suppressive capacity equivalent to that of natural CD4CD25 Tregs (67), whereas Sakaguchi and coworkers (66) reported high suppressive activity after Foxp3 gene tran”
• Regulatory T cells and immune tolerance. (2008, background): “In addition, unlike mice, naive T cells in humans readily express Foxp3 upon TCR stimulation, although the expression is generally much lower and more transient than in natural Tregs (Yagi et al., 2004; Gavin et al., 2006).”
• Foxp3 in control of the regulatory T cell lineage (2007, background): “Similarly, Foxp3 gene transfer confers suppressor function upon naive human CD4 + T cell”