CD4+T Cells: Differentiation and Functions
By Rishi Vishal Luckheeram, R. Zhou, A. Verma, B. Xia. Clinical and Developmental Immunology, 2012
1,384 citations recorded by the source corpus.
CD4+T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4+T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment. Besides the classical T-helper 1 and T-helper 2, other subsets have been identified, including T-helper 17, regulatory T cell, follicular helper T cell, and T-helper 9, each with a characteristic cytokine profile. For a particular phenotype to be differentiated, a set of cytokine signaling pathways coupled with activation of lineage-specific transcription factors and epigenetic modifications at appropriate genes are required. The effector functions of these cells are mediated by the cytokines secreted by the differentiated cells. This paper will focus on the cytokine-signaling and the network of transcription factors responsible for the differentiation of naive CD4+T cells.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/7341178ff9f8215d9ff6e57c77e0c1aad0bfb593
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Citations in the corpus
- Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health (2023, background): “Naïve CD4+ T cells can differentiate into various subsets of Th cells based on specific cytokine secretion profiles through maturational processes that are induced by immune antigenic stimulation orchestrated by APCs such as DCs [42,43].”