Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma.

By Peter E. Fecci, D. Mitchell, J. Whitesides, W. Xie, A. Friedman, G. Archer, J. Herndon, D. Bigner, G. Dranoff, J. Sampson. Cancer Research, 2006

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Subfields: Immunology

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Cancer stem cells in glioblastoma (2015, background): “…of cancer (Hanahan and Weinberg 2011); while the brain possesses a unique series of immune surveillance mechanisms that become active during pathogenic states (Ransohoff and Engelhardt 2012), brain tumors have been characterized as immunosuppressive (Platten et al. 2001; Fecci et al. 2006).”
The microenvironmental landscape of brain tumors (2017, background): “…patients exhibit a decrease in absolute numbers of circulating Th cells; however, there is an increased proportion of immunosuppressive Tregs within the remaining CD4+ cell pool in blood (Fecci et al., 2006a), and a prominent infiltrating Treg population within tumor tissues (Hussain et al., 2006).”