Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.

By B. Beutler, Zhengfan Jiang, P. Georgel, K. Crozat, B. Croker, S. Rutschmann, Xin Du, K. Hoebe. Annual Review of Immunology, 2006

834 citations recorded by the source corpus.

Subfields: Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/c8b16a237b5f46b8ad6de013d140ddba41fff614

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. O. Takeuchi
3. Rafi Ahmed
4. E. Wherry
5. Herbert W. Virgin
6. J. Tschopp
7. E. Seki
8. D. Brenner

In Microbiology

1. O. Takeuchi
2. Shizuo Akira
3. L. Oliveira-Nascimento
4. Rafi Ahmed
5. P. Massari
6. L. Wetzler

Citations in the corpus

• Redefining chronic viral infection. (2009, positive): “Random mutagenesis of the mouse genome suggests that there are about 300 genes that determine resistance to murine CMV (Beutler et al., 2006).”
• Pattern recognition receptors and inflammation. (2010, background): “The innate immune system is the major contributor to acute inflammation induced by microbial infection or tissue damage (Akira et al., 2006; Beutler et al., 2006).”
• Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. (2010, background): “PAMPs comprise two broad classes of biochemical compounds (Beutler et al., 2006): microbial products such as lipopolysaccharide and lipoteichoic acid and nucleic acids derived from pathogens, particularly viruses.”
• The Role of TLR2 in Infection and Immunity (2012, background): “Triacyl LPs are recognized by TLR2/TLR1 while diacyl LPs are recognized by TLR2/TLR6 (Beutler et al., 2006).”
• Toll‐like receptors and adaptor molecules in liver disease: Update (2008, background): “HCV interferes with signals of the (1) TLR3-TRIF-TBK1-IRF-3 pathway, (2) TLRMyD88 pathway, and (3) RIG-I/MDA5-IPS-1 pathway.”
• TAM receptors are pleiotropic inhibitors of the innate immune response. (2007, background): “…mediators of this response are the TLRs, a set of receptors that activate host defenses responsible for local inflammation, the recruitment of effector cells, and the secretion of cytokines that modulate both the innate and adaptive immune responses (Akira et al., 2006; Beutler et al., 2006).”