Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
By Shimon Sakaguchi. Nature Immunology, 2005
2,911 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/59d4e1a8c86867eb04cb1ff1dfd92dca11a0f554
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In Immunology
- Alexander Y. Rudensky
- Shimon Sakaguchi
- Jinfang Zhu
- J. Bluestone
- J. O’Shea
- Ye Zheng
- K. Wing
- Shizuo Akira
Citations in the corpus
- IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells1 (2007, background): “T he T cell response to self and environmental Ags is con-trolled by regulatory/suppressor cell subsets consisting ofheterogeneous CD4 , CD8 , or NKT cell subsets.”
- Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction (2006, background): “CD4+CD25+Foxp3+ regulatory T (T reg) cells also constitute a distinct subset that prevents immune pathology through suppression of pathogenic T cells (11).”
- Foxp3 in control of the regulatory T cell lineage (2007, background): “These observations indicated that Foxp3 mutations might result in a defect in dominant tolerance mediated by regulatory CD25 + CD4 + T cells described by Sakaguchi and colleagues as capable of controlling autoimmunity in a variety of experimental model”
- Opposing regulation of the Il17 locus through direct, reciprocal actions of STAT3 and STAT5 (2011, background): “IL-2 and STAT5 inhibit IL-17 independently of Foxp3 The failure to induce Foxp3 expression has been considered a chief reason for the autoimmunity underlying IL-2 deficienc”
- Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts (2006, background): “In addition, CD4 + CD25 + Foxp3 + regulatory T cells (T reg cells) help to maintain peripheral tolerance by actively suppressing the activation and population expansion of self-reactive T cell”
- Dynamics of the immune reaction to pancreatic cancer from inception to invasion. (2007, background): “Expression of the interleukin 2 (IL-2) receptor a chain CD25 has also been used to identify Treg, albeit with lower sensitivity and specificity than Foxp3 (35, 36).”
- Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease (2007, background): “The Journal of Experimental Medecine, The Rockefeller University Press, 2007, 204 (1), pp.”