IL-22 increases the innate immunity of tissues.

By K. Wolk, S. Kunz, Ellen Witte, M. Friedrich, K. Asadullah, R. Sabat. Immunity, 2004

1,453 citations recorded by the source corpus.

Subfields: Dermatology, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/b2c82d990c8bbb549ce628a68528db9e9fb9dfd2

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Citations in the corpus

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells (2009, background): “org/molecule/query?afcsid=A001245">A001245 ) and IL-22R, and is expressed on epithelial cells of organs in the digestive and respiratory tracts and the skin but not on immune cells, such as T cells, B cells, monocytes or dendritic cell”
Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. (2007, background): “IL-22R is expressed strongly in the liver, as well as the skin, lungs, pancreas, and other peripheral tissues (Aggarwal et al., 2001; Wolk et al., 2004).”
Th17 cell differentiation: the long and winding road. (2008, positive): “The Th17 factors RORgt, IL-17, IL-22, and IL-23 mRNA are all elevated in psoriatic lesional skin (Lee et al., 2004; Teunissen et al., 1998; Wilson et al., 2007; Wolk et al., 2004 ).”
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia (2008, background): “that was originally thought to be predominantly expressed in T H 1 cells and has been shown to induce the antimicrobial peptides human β-defensin 2 and β-defensin 3; with IL-17A, IL-22 augments expression of the calcium-binding proteins S100A7, S100A8 and S100A9 in skin keratinocyte”
Pathogenesis and therapy of psoriasis (2007, background): “Upstream activators may well be IFNs for STAT1, and TNF or IL-1 for NF-κB, but more recently discovered cytokines such as IL-20 and IL-22 also have the ability to activate STAT and NF-κB pathway”
IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis (2006, methodology): “IL-22 also induces mRNA and protein expression of acute phase proteins such as serum amyloid A, a1antichymotrypsin, and haptoglobin in liver cells in vitro and in vivo [8, 16 ].”
Interleukin-22: immunobiology and pathology (2015, background): “Although initial studies did not identify IL-22R expression in the thymus by PCR (279, 338), subsequent analysis of protein expression revealed a population of thymic epithelial cells (138).”
JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects (2017, background): “IL-17 is critical for immune responses to extracellular bacteria and fungi, and IL-22 promotes barrier integrity [51, 52].”