Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation.

By Lauren A. Zenewicz, G. Yancopoulos, D. Valenzuela, A. Murphy, M. Karow, R. Flavell. Immunity, 2007

668 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/1c294a926e4203041ee3fef0133a2d9007318953

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In Genetics

1. F. Powrie
2. D. Artis
3. P. Murray
4. F. Tacke
5. J. O’Shea
6. L. Hammerich

In Immunology

1. D. Artis
2. D. Cua
3. V. Kuchroo
4. H. Spits
5. R. Flavell
6. T. Korn
7. M. Oukka
8. G. Eberl

In Oncology

1. R. Flavell
2. V. Kuchroo
3. M. Colonna
4. P. Murray
5. F. Tacke
6. J. O’Shea
7. D. Cua
8. Shomyseh Sanjabi

Citations in the corpus

• Hepatic inflammatory responses in liver fibrosis (2023, positive): “IL-22 agonism improves liver inflammation in mice with acute-on-chronic liver failure 124 , protects hepatocytes from injury during acute hepatitis 125 and reduces liver fibrosis in carbon tetrachloride (CCl 4 )- treated mice through induction of HSC senescence 126 .”
• Fatty acid-induced NLRP3-PYCARD inflammasome activation interferes with insulin signaling (2011, neutral): “Because the liver is one of the main target organs of insulin, we used FL38B, a mouse liver cell lin”
• Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells (2009, background): “IL-22 seems to be important in many diseases, including hepatitis and psoriasis; however, in many cases it is still uncertain whether IL-22 ameliorates or exacerbates the diseas”
• Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease (2008, methodology): “NK Cell Stimulation Spleens and lymph nodes were isolated from C57BL/6 mice and prepared as described previously (Zenewicz et al., 2007), and NK1.”
• Anti- and Pro-inflammatory Roles of TGF-β, IL-10, and IL-22 In Immunity and Autoimmunity (2009, background): “be protective in acute inflammatory models, such as hepatitis, as well as during chronic inflammation such as inflammatory bowel disease [46 ,52,61].”
• Th17 cells in human disease (2008, background): “Others have found, however, that IL-22 protects hepatocytes during acute liver inflammation (49); thus, IL-22 produced by Th17 cells may enhance inflammation or limit tissue damage induced by IL-17, depending on the type of tissue.”