Pathogenesis and therapy of psoriasis

By M. Lowes, A. Bowcock, J. Krueger. Nature, 2007

1,810 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/89e0900d6d77c0377c2afacc0b949181211ec184

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In Immunology

Citations in the corpus

Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab (2011, background): “These targeted therapies contrast with broad immunosuppressive agents, such as methotrexate, that have been the standard of care for several immune-mediated disorders, such as psoriasi”
The IL-1 family: regulators of immunity (2010, background): “It is thought to be driven by T H 1 and T H 17 cells, although there is also an epidermal componen”
Skin immune sentinels in health and disease (2009, background): “The current view of psoriasis pathogenesis proposes that a combination of environmental and genetic factors confers susceptibility to the disease and that a dysregulated immune response leads to a series of linked cellular changes in the ski”
Targeting phosphoinositide 3-kinase: moving towards therapy. (2008, background): “Other diseases, where PI3K inhibition has a therapeutic potential are: i) psoriasis, in which T-cells, neutrophils, and macrophages are implicated [120,121], and ii) chronic obstructive pulmonary disease (COPD), which is mainly driven by macrophages, but also requires T-cells and neutrophils [122,12”
MicroRNAs in development and disease. (2011, background): “In psoriasis, keratinocytes’ proliferation is enhanced as their differentiation is retarded (382), rendering it hard to reconcile the function of miR-203 in psoriasis with its role in skin morphogenesis.”
MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis? (2007, background): “SOCS-3 deficiency leads to sustained activation of STAT3 in response to IL-6 [18], a cytokine present in the psoriasis lesions [11].”
Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. (2008, background): “It has been postulated that IL-17 may be important in psoriasis (Blauvelt, 2007; Lowes et al., 2007; Nickoloff, 2007).”
The biological functions of T helper 17 cell effector cytokines in inflammation. (2008, positive): “In addition, abnormal Th1 cell responses have been demonstrated to mediate, at least in part, many other autoimmune diseases, including psoriasis and inflammatory bowel disease (IBD) (Bouma and Strober, 2003; Lowes et al., 2007).”
Immunology of Psoriasis (2014, background): “The classic histological features of psoriasis can help explain the clinical appearance, demonstrated by hematoxylin and eosin stain (Figure 3c) (36).”