IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

By S. Aujla, Yvonne R. Chan, M. Zheng, M. Fei, D. J. Askew, D. Pociask, T. Reinhart, F. McAllister, Jennifer Edeal, K. Gaus and 8 more. Nature Medicine, 2008

1,277 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Immunology

View Paper: https://www.semanticscholar.org/paper/b95c1c430feda4d786990f1f38c5f7dbf68eec93

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Emergency Medical Services

1. B. B. Finlay
2. Dan R. Littman

In Immunology

1. Dan R. Littman
2. D. Cua
3. V. Kuchroo
4. R. Flavell
5. C. Dong
6. T. Korn
7. M. Oukka
8. E. Bettelli

Citations in the corpus

• CD4+T Cells: Differentiation and Functions (2012, background): “IL22 participates actively in mucosal host defense against bacterial pathogens, by inducing antimicrobial peptides and increasing cell proliferation [144].”
• Anti- and Pro-inflammatory Roles of TGF-β, IL-10, and IL-22 In Immunity and Autoimmunity (2009, background): “For example, it has been shown that IL-22 is crucial for control of pulmonary Klebsiella pneumoniae infection or infection of the gastrointestinal tract with Citrobacter rodentium [62,63].”
• Functional specialization of interleukin-17 family members. (2011, background): “Although Il17ra / mice were not more susceptible to Mycobacterium tuberculosis infection (Aujla et al., 2008), the IL-23-IL-17A pathway was required for Th1 cell-type immune responses that protected the host against the intracellular pathogen Francisella tularensis (Lin et al.”
• Cytokine signaling modules in inflammatory responses. (2008, background): “…et al., 2008; Wolk et al., 2004; Zheng et al., 2007), and recent studies that show protective roles of IL-22 in mucosal defense against pathogens (Aujla et al., 2008; Zheng et al., 2008), in which IL-22 induces the expression of antimicrobial proteins, including S1008A, a zinc and manganese…”
• Interleukin-22: immunobiology and pathology (2015, background): “Lo YH, Torii K, Saito C, Furuhashi T, Maeda A, Morita A. Serum IL-22 correlates with psoriatic severity and serum IL-6 correlates with susceptibility to phototherapy.”
• Specific microbiota direct the differentiation of Th17 cells in the mucosa of the small intestine (2008, positive): “…to participate in inflammatory responses and to have critical functions in host defense against bacterial and fungal pathogens, particularly those encountered at mucosal surfaces (Aujla et al., 2007, 2008; Bettelli et al., 2007; Khader et al., 2007; McKenzie et al., 2006; Ouyang et al., 2008).”
• The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells (2011, background): “IL-22 has been shown to induce the production of antimi- crobial peptides and mucins by epithelial cells, thus playing an important role in maintaining mucosal immunity and integrity (Aujla et al., 2008; Sugimoto et al., 2008; Zheng et al., 2008).”
• Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. (2008, result): “We found that intestinal Il22 transcripts were strongly reduced in the LPLs of mice deficient in both Rag2 and the common g chain (Rag2 / Il2rg / mice; Figure 5A), confirming the previous observations on the role of gc-dependent signals in IL-22 production (Aujla et al., 2008).”
• Klebsiella pneumoniae: Going on the Offense with a Strong Defense (2016, background): “Specifically, depletion of IL-22 with a neutralizing antibody led to increased bacterial loads in the lungs and rates of mortality (187), while overexpression or the therapeutic administration of IL-22 ameliorated K.”
• Homeostasis of naive and memory T cells. (2008, background): “Here, local release of IL-22 by Th-17 cells could be important for protecting the gut lining (Aujla et al., 2008; Zheng et al., 2008).”