Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

By Y. Surh, J. Kundu, H. Na. Planta Medica, 2008

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Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. (2011, neutral): “Molecular Aspects of Medicine (2011), doi:10.1016/j.mam.2011.10.006 eicosanoids (Tai et al., 2002).”
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution (2011, background): “Activation of Nrf2 appears to be regulated by phosphorylation-signaling pathways, including MAPKs (mitogen-activated protein kinases), PI3K (phosphatidylinositol 3-kinase), protein kinase C (PKC) and CK2 (casein kinase 2) (Surh et al. 2008).”
Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives (2015, neutral): “Nrf2 can be activated by various mechanisms, including stabilization of Nrf2 via Keap1 cysteine thiol modification and phosphorylation of Nrf2 by upstream kinases [170,171].”
When NRF2 Talks, Who's Listening? (2010, neutral): “These covalent modifications control intracellular distribution, transcriptional activity, and stability of transcription factors, including NRF2 (81, 143).”
Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions (2012, background): “These have been exceptionally well discussed by Surh and colleagues [21] and are summarized in Table 1.”