Oxidative Stress and Oxidative Damage in Carcinogenesis

By J. Klaunig, L. Kamendulis, B. A. Hocevar. Toxicologic pathology (Print), 2010

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Oxidative Stress in Aging Human Skin (2015, background): “Other redox sensitive “switches” are transcription factors such as AP-1, NF- B, NF-E2 related factor-1 (Nfr1), NF-E2 related factor-2 (Nrf2) and Egr1 (early growth response 1) [306,321,322] that modulate gene expression [298] which”
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases (2016, neutral): “HIF-1a Cell adaption to oxygen tension modifications [52] Cell proliferation; angiogenesis [77] Cell transformation [78, 79]”
Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013, background): “proliferation and survival, thus aberrant activation can paly a role in potential mechanisms of carcinogenesis [148].”
The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state (2015, background): “These sequential events ultimately lead to either normal cell proliferation or development of cancer inflammatory conditions, aging, and two common agerelated diseases – diabetes mellitus and atherosclerosis [40–43].”