ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis

By B. D'Autréaux, M. Tolédano. Nature reviews. Molecular cell biology, 2007

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How researchers see this paper

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Reconciling the chemistry and biology of reactive oxygen species. (2008, background): “However, when considering its role in cell signaling or oxidative stress, most emphasis is currently given to direct reactions with specific thiol protein”
Mitochondrial electron transport chain, ROS generation and uncoupling (Review) (2019, background): “This permanent and stable oxidant molecule, which freely disperses through the outer membrane of mitochondria, acts as an intracellular signaling molecule, physiologically functioning via the direct modification of amino acids (61).”
Radical-free biology of oxidative stress. (2008, background): “Such changes in protein structure and interaction due to reversible oxidation can provide a central mechanism for specificity in redox signaling (34).”
Ischemia/Reperfusion (2016, neutral): “acting with other regulatory/effector proteins (168,398,414).”