Programmed cell senescence during mammalian embryonic development.

By D. Muñoz‐Espín, M. Cañamero, A. Maraver, G. Gómez-López, Julio Contreras, S. Murillo-Cuesta, A. Rodríguez-Baeza, I. Varela-Nieto, J. Ruberte, M. Collado and 1 more. Cell, 2013

1,299 citations recorded by the source corpus.

Subfields: Cancer Research, Physiology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/9e30edd74ab37e36e6eca2c4e02e043c44ab1439

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Citations in the corpus

Unmasking Transcriptional Heterogeneity in Senescent Cells (2017, background): “Senescent cells participate in a variety of physiological and pathological conditions, including tumor suppression [2], embryonic development [3, 4], tissue repair [5–8], and organismal aging [9].”
Senescence and aging: Causes, consequences, and therapeutic avenues (2018, background): “Senescence, a cellular response that limits the proliferation of aged or damaged cells (Muñoz-Espín et al., 2013; Muñoz-Espín and Serrano, 2014), belongs to the antagonistic class (Fig.”
Senescence is a developmental mechanism that contributes to embryonic growth and patterning. (2013, background): “While we, and the accompanying study (Muñoz-Espı́n et al., 2013), identify p21 as one mediator of developmental senescence, precisely how p21 contributes to the regulation of developmental senescence remains to be determined.”
Senescence and the SASP: many therapeutic avenues (2020, background): “…Spring Harbor Laboratory Press; ISSN 0890-9369/20; www.genesdev.org 1565 Immune-mediated clearance of senescent cells suppresses tumor initiation (Kang et al. 2011), contributes to tumor regression (Xue et al. 2007), and is essential during development (Muñoz-Espín et al. 2013; Storer et al. 2013).”
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells (2017, neutral): “These newly recognised senescent phenotypes, termed the senescence-associated secretory phenotypes 9 , reportedly contribute to tumour suppression 7,8 , wound healing 11 , embryonic development 12,13 and even tumorigenesis promotion 9,14 .”
Cellular Senescence: Defining a Path Forward. (2019, background): “SASP factors mediate developmental senescence (Mun˜oz-Espı´n et al., 2013; Storer et al., 2013), wound healing (Demaria et al., 2014), and tissue plasticity (Mosteiro et al., 2016) and also contribute to persistent chronic inﬂammation (known as inﬂammaging) (Franceschi and Campisi, 2014).”
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA. (2026, background): “However, recent reports showed a beneficial role for the SASP during embryonic development (Muñoz-Espı́n et al., 2013; Storer et al., 2013) and a role in limiting fibrosis after tissue injury (Jun and Lau, 2010; Krizhanovsky et al.”
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging (2017, background): “The SASP influences the cellular microenvironment, which can be beneficial early in life or in an acute setting of wound healing (Demaria et al., 2014; Muñoz-Espı́n et al., 2013).”
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “Senescence together with apoptosis is recognized to play an important physiological role in normal embryonic development, in ongoing tissue homeostasis throughout life (91, 92), but is increasingly considered to have a role in causing or exacerbating aging and age-related diseases (91, 93–95).”
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 (2015, background): “This pathway can positively contribute to normal development and wound healing (15, 17, 61, 62).”
Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Therefore, embryonic development is a robust process in which senescence plays an important, albeit nonessential, role (235, 305).”