Senescence and the SASP: many therapeutic avenues
By Jodie Birch, Jesús Gil. Genes & Development, 2020
993 citations recorded by the source corpus.
In this review, Birch and Gil summarize the regulation and functions of senescence-associated secretory phenotype (SASP) and highlight the therapeutic potential of SASP modulation as complimentary, or an alternative to, current senolytic approaches.
Subfields: Immunology, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/e68894d2370c9e870909dce14d17781845f869b4
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In Immunology
In Molecular Biology
In Physiology
Citations in the corpus
- Hallmarks of Cancer: New Dimensions. (2022, background): “Senescence can be induced in cells by a variety of conditions, including microenvironmental stresses such as nutrient deprivation and DNA damage, as well as damage to organelles and cellular infrastructure, and imbalances in cellular signaling networks (115, 117), all of which have been associated w”
- Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “These two types of senescence share many regulatory molecules, and they both cause cell cycle arrest mainly through the p53/p21 and p16Ink4a/ retinoblastoma protein signaling pathways.(155,156) The number of senescent cells increases with age, obesity, and diabetes, and clearing senescent cells can ”
- Inflammation and aging: signaling pathways and intervention therapies (2023, background): “Interestingly, some of these components overlap with aging markers observed in human plasma, including serine protease inhibitors, stanniocalcin 1, and growth differentiation factor 15.190 Furthermore, dysfunctional mitochondria,195 persistent DNA damage response,196 CCAAT/enhancer-binding protein β”