Exosomes maintain cellular homeostasis by excreting harmful DNA from cells
By Akiko Takahashi, Ryo Okada, Koji Nagao, Yuka Kawamata, A. Hanyu, S. Yoshimoto, M. Takasugi, Sugiko Watanabe, Masato T. Kanemaki, C. Obuse and 1 more. Nature Communications, 2017
684 citations recorded by the source corpus.
Emerging evidence is revealing that exosomes contribute to many aspects of physiology and disease through intercellular communication. However, the biological roles of exosome secretion in exosome-secreting cells have remained largely unexplored. Here we show that exosome secretion plays a crucial role in maintaining cellular homeostasis in exosome-secreting cells. The inhibition of exosome secretion results in the accumulation of nuclear DNA in the cytoplasm, thereby causing the activation of cytoplasmic DNA sensing machinery. This event provokes the innate immune response, leading to reactive oxygen species (ROS)-dependent DNA damage response and thus induce senescence-like cell-cycle arrest or apoptosis in normal human cells. These results, in conjunction with observations that exosomes contain various lengths of chromosomal DNA fragments, indicate that exosome secretion maintains cellular homeostasis by removing harmful cytoplasmic DNA from cells. Together, these findings enhance our understanding of exosome biology, and provide valuable new insights into the control of cellular homeostasis. The role of exosomes in intercellular communication is well established, however less in known about the biological roles of exosome secretion in exosome-secreting cells. Here the authors show that exosome secretion controls cellular homeostasis in exosome-secreting cells by removing harmful cytoplasmic DNA from cells.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/2915317c018c96f63e137c71be9d5b2fdcf2d811
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In Cancer Research
In Molecular Biology
Citations in the corpus
- Exosomes in cancer development, metastasis, and immunity (2019, background): “Thus, exosome secretion of harmful cytoplasmic DNA from cells supported cell survival and maintained cellular homeostasis [55].”
- The biology, function, and biomedical applications of exosomes (2020, neutral): “Although exosomal DNAuptake by recipient cells alters their signaling, exosome biogenesis may also play a role in clearing cytoplasmic DNA and in preventing activation of the cytosolic DNA-sensing machinery and reactive oxygen species–dependent DNAdamage response (76).”
- The senescence-associated secretory phenotype and its physiological and pathological implications (2024, neutral): “Secreted CCFs elicit DNA damage responses in recipient cells 68 .”