Senescence and aging: Causes, consequences, and therapeutic avenues

By Domhnall McHugh, Jesús Gil. Journal of Cell Biology, 2018

1,060 citations recorded by the source corpus.

McHugh and Gil review the role of senescence in age-related diseases and how targeting senescence may improve health span and extend life span.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Mechanisms and functions of cellular senescence. (2018, neutral): “Nicolás Herranz 1,2 and Jesús Gil Overall, therapeutic approaches aiming to modulate senescent phenotypes will benefit from a better understanding of the steps driving and defining the evolution of senescent cells in vitro.”
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021, background): “…limit damage by restraining proliferation and fibrosis during carcinogenesis and active tissue repair whereas anti-senescence agents enable elimination of accumulated senescent cells to restore tissue function, and potentially aid organ rejuvenation (McHugh and Gil, 2018; Gorgoulis et al., 2019).”
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “Through the SASP, the senescent cell has an important influence on the extrinsic microenvironment, which suggests a link between senescence and alterations in intracellular and intercellular communications (93).”