An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA.

By M. Demaria, Naoko Ohtani, S. Youssef, F. Rodier, Wendy Toussaint, James R. Mitchell, Rémi-Martin Laberge, J. Vijg, H. van Steeg, M. Dollé and 4 more. Developmental Cell, 2026

1,614 citations recorded by the source corpus.

Citation for published version (APA): Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., Hoeijmakers, J. H. J., de Bruin, A., Hara, E., & Campisi, J. (2014). An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental Cell, 31(6), 722-733. https://doi.org/10.1016/j.devcel.2014.11.012

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Citations in the corpus

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 (2015, background): “GATA4 also activates expression of miR-146a, which dampens the activation of NF-kB (17).”
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017, unknown): “Although growth arrested, senescent cells are highly metabolic and exhibit a senescence-associated secretory phenotype (SASP), producing factors that have profound effects on neighboring cells such as proinflammatory cytokines (IL-6, IL-8, TNF-α, monocyte chemoattractant protein 1 [MCP-1]), VEGF, MM”
Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Accordingly, mice carrying a mutant form of CCN1, thus unable to induce senescence, or p16–3MR mice deprived of senescent cells display increased collagen deposition and enhanced fibrosis (89, 173).”
Cellular senescence promotes adverse effects of chemotherapy and cancer relapse (2016, methodology): “5 day embryos were dissected and cultured to produce MEFs, and fibroblasts were derived from the dorsal skin of 3 mo old mice, as described (15).”
Fibroblasts: origins, definitions, and functions in health and disease (2021, background): “When the damage is healed, myofibroblasts revert to quiescence and, in some instances, prune via apoptosis or senescence (Demaria et al., 2014; Wilkinson et al., 2019).”
Cellular Senescence: A Translational Perspective (2017, background): “Apart from potentially delaying wound healing, as suggested from studies of genetic clearance of senescent cells from mice (Demaria et al., 2014), little information is available about possible side-effects of senolytics besides known sideeffects of repurposed senolytic compounds when used in other…”
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells (2017, unknown): “These newly recognised senescent phenotypes, termed the senescence-associated secretory phenotypes 9 , reportedly contribute to tumour suppression 7,8 , wound healing 11 , embryonic development 12,13 and even tumorigenesis promotion 9,14 .”
Cellular senescence mediates fibrotic pulmonary disease (2017, unknown): “Conversely, senescence is autonomously anti-proliferative, may be requisite for optimal cutaneous wound healing 9 and may restrict pathological liver ﬁbrosis 10 .”
Hallmarks of Cellular Senescence. (2018, unknown): “For example, senescent cells associated with tissue repair express several MMPs and growth factors, such as PDGF-A and VEGF [6,78], while age-associated or therapy-induced senescent cells are mainly associated with inflammatory factors [79,80].”