Senescence is a developmental mechanism that contributes to embryonic growth and patterning.

By M. Storer, A. Mas, A. Robert-Moreno, M. Pecoraro, M. C. Ortells, Valeria Di Giacomo, Reut Yosef, Noam Pilpel, V. Krizhanovsky, J. Sharpe and 1 more. Cell, 2013

1,081 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/b4f4b76077d9439a136aadb774bb5251609c25fc

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Citations in the corpus

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines (2018, background): “Senescence together with apoptosis is recognized to play an important physiological role in normal embryonic development, in ongoing tissue homeostasis throughout life (91, 92), but is increasingly considered to have a role in causing or exacerbating aging and age-related diseases (91, 93–95).”
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 (2015, background): “This pathway can positively contribute to normal development and wound healing (15, 17, 61, 62).”
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells (2017, positive): “These newly recognised senescent phenotypes, termed the senescence-associated secretory phenotypes 9 , reportedly contribute to tumour suppression 7,8 , wound healing 11 , embryonic development 12,13 and even tumorigenesis promotion 9,14 .”
Senescence and the SASP: many therapeutic avenues (2020, background): “…Spring Harbor Laboratory Press; ISSN 0890-9369/20; www.genesdev.org 1565 Immune-mediated clearance of senescent cells suppresses tumor initiation (Kang et al. 2011), contributes to tumor regression (Xue et al. 2007), and is essential during development (Muñoz-Espín et al. 2013; Storer et al. 2013).”
Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Therefore, embryonic development is a robust process in which senescence plays an important, albeit nonessential, role (235, 305).”
Senescence and aging: Causes, consequences, and therapeutic avenues (2018, background): “Senescence has also physiological roles during normal development (Muñoz-Espín et al., 2013; Storer et al., 2013), acting in concert with apoptosis to facilitate embryonic morphogenesis.”
Cellular Senescence: Defining a Path Forward. (2019, positive): “SASP factors mediate developmental senescence (Mun˜oz-Espı´n et al., 2013; Storer et al., 2013), wound healing (Demaria et al., 2014), and tissue plasticity (Mosteiro et al., 2016) and also contribute to persistent chronic inﬂammation (known as inﬂammaging) (Franceschi and Campisi, 2014).”
Unmasking Transcriptional Heterogeneity in Senescent Cells (2017, background): “Senescent cells participate in a variety of physiological and pathological conditions, including tumor suppression [2], embryonic development [3, 4], tissue repair [5–8], and organismal aging [9].”
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “Waves of cellular senescence (followed by RCD) appear to contribute to developmental embryogenesis (although in a dispensable manner) [6, 946, 947] as well as to multiple pathophysiological processes in the adult, including tissue repair and regeneration, immunity, preservation of the stem cell comp”