Corpse clearance defines the meaning of cell death

By J. Savill, Valerie Fadok. Nature, 2000

1,675 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/86334a45d1666f4ec013161033e6caaa655d3309

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Guido Kroemer
2. L. Zitvogel
3. Oliver Kepp
4. S. Fink
5. Arlene H. Sharpe
6. J. Ameisen
7. G. Dranoff
8. G. Freeman

In Physiology

1. Guido Kroemer
2. M. Jäättelä
3. Marcel Leist
4. L. Zitvogel
5. Susan A. Elmore
6. W. Bursch
7. F. Aloisi
8. J. Ameisen

Citations in the corpus

• The autophagosomal–lysosomal compartment in programmed cell death (2001, background): “In case of phagocytosis, ligation of external particles such as apoptotic bodies to the phagocyte membrane initiates its reorganisation; the ligation appears to be driven by surface tags of apoptotic bodies or by release of soluble factors from dying cells targeted at receptors of the phagocytes.(5,”
• Inflammation, a Key Event in Cancer Development (2006, background): “job by inducing apoptosis and conducting phagocytosis (10-12).”
• Lysosomes and autophagy in cell death control (2005, background): “The importance of lysosomes and lysosomal hydrolases ( Box 1 ) in the clean-up phase of apoptosis (that is, the engulfment and digestion of dying and dead cells by neighbouring cells or phagocytes), and in cellular and tissue autolysis during uncontrolled necrosis is well establishe”
• Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. (2003, background): “PS, in turn, is recognized by a recently cloned PS Cleveland Clinic Foundation receptor whose blockade abrogates the engulfment of Cleveland, Ohio 44195 apoptotic cells by macrophages (Fadok et al., 2000; 5 Department of Radiation Oncology Savill and Fadok, 2000).”
• Cell Death Pathways in Photodynamic Therapy of Cancer (2011, background): “Cleavage of cytoskeletal proteins leads to cell fragmentation and formation of apoptotic bodies [23].”
• Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis (2007, background): “mediators and stimulate secretion of TGFβ1 and IL-10 by inflammatory MPs (43-46).”
• Apoptosis: A Review of Programmed Cell Death (2007, background): “Because apoptotic cells do not release their cellular constituents into the surrounding interstitial tissue and are quickly phagocytosed by macrophages or adjacent normal cells, there is essentially no inflammatory reaction (Savill and Fadok, 2000; Kurosaka et al., 2003).”
• Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. (2004, background): “org Volume 113 Number 9 May 2004 1323 The regulation of innate immunity is complex, but its persistence or termination results, at least in part, from the prolonged survival, on the one hand, or the apoptosis, on the other, of its cellular effectors (53, 54).”
• Death and anti-death: tumour resistance to apoptosis (2002, neutral): “After exposure of 'eat me' signals (for example, exposure of phosphatidylserine and changes in surface sugars), the remains of the dying cell are engulfed by phagocyte”
• Inflammatory Resolution: new opportunities for drug discovery (2004, background): “, or death by either apoptosis or necrosis followed by phagocytosis, with apoptosis followed by phagocytosis being considered the most desirable for successful resolutio”
• Immune function of microglia (2001, background): “, 2000), may cooperate to ensure efficient elimination of pathogens or infected cells and induction of adaptive immune responses (Savill and Fadok, 2000; Ehlers, 2000).”
• Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion (2004, background): “Here, it is engaged by phosphatidylserine receptor–bearing constitutive phagocytes, resulting in macropinocytosis of the affected membrane.(45) Apoptosis also causes activated complement to be deposited on the cell surface, further promoting phagocytosis, via macrophage complement receptors,(46) of ”
• Anti-inflammatory lipid mediators and insights into the resolution of inflammation (2002, background): “Apoptosis and the clearance of apoptotic cells have been recognized as important mechanisms for the resolution of inflammation in vivo”