Inflammation, a Key Event in Cancer Development

By Haitian Lu, W. Ouyang, Chuanshu Huang. Molecular Cancer Research, 2006

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Deubiquitination and Stabilization of PD-L1 by CSN5 (2016, background): “The key upstream mediators linking inflammation to cancer include interleukin-6 (IL-6), tumor necrosis factor alpha (TNFa), nuclear factor kB (NF-kB), inducible nitric oxide synthase, cyclooxygenase 2, and hypoxia-inducible factor 1 alpha (HIF1a) (Lu et al., 2006).”
Inflammation: gearing the journey to cancer. (2008, background): “growth, development, differentiation, wound healing and immune response [61,65].”
The epigenomics of cancer. (2007, background): “…cancer in Figure 2, in which risk factors for common cancers such as aging (Sharpless and DePinho, 2005) and inflammation (Coussens and Werb, 2002; Lu et al., 2006; Nelson et al., 2004) are depicted as causing such expansions in either normal colon epithelial stem cells or precursor cells derived…”
Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “The metastatic potential of chemokines has been attributed to their ability to induce the expression of MMPs, which facilitate tumor invasion (197, 345).”
Inflammation and cancer: An ancient link with novel potentials (2007, background): “(NFAT) have been reported as key molecular players linking inflammation to cancer.(11) This review focuses primarily on some key molecular components and pathways that may be responsible for inflammation-associated cancer.”