Anti-inflammatory lipid mediators and insights into the resolution of inflammation

By T. Lawrence, D. Willoughby, D. Gilroy. Nature reviews. Immunology, 2002

910 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/3a3c19d8ff4983b1917c69bf2d5023074ee79d99

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In Immunology

1. A. Mantovani
2. A. Sica
3. C. Serhan
4. M. Locati
5. Subhra K. Biswas
6. M. Galdiero
7. K. Ren
8. A. Sher

In Molecular Biology

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2. K. Ren
3. Subhra K. Biswas
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In Nutrition and Dietetics

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3. Chia Nan
4. Rong Yang
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6. P. Calder
7. B. Levy
8. D. Mozaffarian

Citations in the corpus

• Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1 (2005, background): “2 c); it is characterized by a cavity and a lining composed of both fibroblast-like and macrophage-like cells (10).”
• Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids (2005, background): “IL-10, TGFβ).[149] It is a general observation that adverse effects of Glucocorticoids counteract the acute inflammaglucocorticoid treatment appear more likely after tory effects on the microcirculation resulting in long-term treatment but less frequently after shortvasoconstriction, reduction of oe”
• Resolution of inflammation: the beginning programs the end (2005, neutral): “We argue here that events occurring early in acute inflammation engage an active and coordinated 'resolution program' involving a switch to local production of specialized intercellular messengers, programmed leukocyte death by apoptosis and subsequent clearance of dying cells by phagocytes that the”
• Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses (2004, background): “Not all hyppos, however, are immunostimulatory and some are even inhibitor”
• Adenosine: an endogenous regulator of innate immunity. (2004, background): “At later stages of immune or inflammatory processes, adenosine contributes to the resolution of inflammation, both by downregulating macrophage activation and by advancing Th2- versus Th1-cell development [ 54 ].”
• Macrophage plasticity and polarization in tissue repair and remodelling (2013, background): “Lipid mediators play a key role in the orchestration of inflammation and its resolution [84,85].”
• Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice (2010, background): “Both apoptosis as well as the efficient clearance of apoptotic cells are important determinants of the resolution of inflammation in vivo [54,55,56].”
• Interactions between the immune and nervous systems in pain (2010, background): “They participate in innate host defense and allergic reactions and are degranulated within minutes of an inflammatory reaction, resulting in the release of histamine, bradykinin and other mediators that contribute to vasodilatio”