Inflammatory Resolution: new opportunities for drug discovery

By D. Gilroy, T. Lawrence, M. Perretti, A. Rossi. Nature reviews. Drug discovery, 2004

806 citations recorded by the source corpus.

Subfields: Immunology, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/206cd47309aca606764c0d3793795370acbceb17

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. C. Serhan
2. M. Karin
3. T. Lawrence
4. V. Nizet
5. D. Gilroy
6. M. Perretti
7. Chia Nan
8. Michael R Hamblin

In Pharmacology

1. C. Serhan
2. Chia Nan
3. M. Karin
4. Michael R Hamblin

In Physiology

1. C. Serhan
2. M. Karin
3. Michael R Hamblin

Citations in the corpus

• Pro-Resolving lipid mediators and Mechanisms in the resolution of acute inflammation (2014, background): “drugs towards those that are “resolution friendly” replacement therapies (Chiang et al., 2008; Gilroy et al., 2004; Schwab et al., 2007).”
• Resolution of inflammation: state of the art, definitions and terms (2006, background): “Consistently, agonists at receptor targets utilized by endogenous anti-inflammatory proresolving mediators exert an anti-inflammatory effect when added back into experimental models/specific settings in the laboratory (4, 5).”
• Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “Gene disruption studies and pharmacological inhibition have outlined a role for these mediators in negative regulation of inflammation and inflammatory disease (Gilroy et al., 2004).”
• Acute and Impaired Wound Healing: Pathophysiology and Current Methods for Drug Delivery, Part 1: Normal and Chronic Wounds: Biology, Causes, and Approaches to Care (2012, background): “However, studies suggest that anti-inflammatory cytokines, such as TGF-A1 and interleukin 1, and bioactive lipids, such as cyclopentenone prostaglandin, lipoxins, and resolvins, take part in this process.(6,7) The exact role of these entities during inflammatory phase resolution is under investigati”
• Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators (2008, background): “Resolution of inflammation: new concepts The resolution of inflammation was defined in modern molecular terms relatively recentl”