Immune function of microglia

By F. Aloisi. Glia, 2001

1,308 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5b22692ae6900da7e1c62c1973c4fb241ca72ce1

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In Immunology

In Neurology

Citations in the corpus

Autoimmune T cell responses in the central nervous system (2009, background): “By contrast, during inflammation microglial cells express MHC class II and co-stimulatory molecule”
The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. (2006, background): “B activation, RANTES, and pro-inflammatory cytokines (Aloisi, 2001; Hu et al., 1999; Vincent et al., 1997).”
Microglial physiology: unique stimuli, specialized responses. (2009, background): “Isolation of adult microglia and neonatal microglia shows these cells to be poor or immature APCs, although treatment with granulocyte macrophage colony-stimulating factor (GM-CSF) will lead to differentiation to a more DC-like phenotype (26).”
Inflammation as a causative factor in the aetiology of Parkinson's disease (2007, background): “This combination of released factors and surface adhesion to dopaminergic neurons leads to a progressive and irreversible neuronal cell death, which is worsened by the release of chemoattractants by the dying neurons to induce even greater infiltration of the region by activated microglia (Aloisi, 2”
Inflammatory mechanisms in ischemic stroke: role of inflammatory cells (2010, background): “Microglial cells, the resident macrophages of the brain, are activated rapidly in response to brain injury [30, 31].”
Selective Neuronal Vulnerability to Oxidative Stress in the Brain (2010, neutral): “While these glial responses are benefi cial to neurons, the continuous or repeated activation of astrocytes and microglia under conditions of chronic infl ammatory stresses can lead to the increased production of ROS/RNS and other neurotoxic mediators, which can lead to severe neuronal damage (Banat”
Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy (2003, background): “Both microglia and astroglia have the ability to release proinflammatory cytokines in response to nerve injury and inflammation (Aloisi, 2001; Dong and Benveniste, 2001).”
Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2 (2008, background): “In JHMV-infected mice and in other CNS infections, cytokines are generally expressed by glia and infiltrating cells, especially astrocytes and macrophages (3, 42, 47).”
Neuroinflammation in Parkinson’s disease: its role in neuronal death and implications for therapeutic intervention (2009, background): “release of chemoattractants by the dying DA neurons (Aloisi, 2001; Kim and De Vellis, 2005; Sriram et al., 2006) are likely to promote”
Broad Expression of Toll‐Like Receptors in the Human Central Nervous System (2002, background): “While data on TLR expression in the rodent CNS are beginning to emerge, no information is currently available on TLR expression by human glial cells.”
Interleukin-1 and neuronal injury (2005, background): “However, similar to astrocytes, microglial cells can also produce anti-inflammatory molecules, which are potentially beneficia”
Microglia as a source and target of cytokines (2002, background): “Microglia faces a unique ensemble of neighboring cell types they serve to protect (Aloisi, 2001).”
Role of Microglia in Neurotrauma (2010, neutral): “Activated microglia and macrophages demonstrate gene expression profiles that reflect an increase in phagocytosis, upregulation of antigenpresenting capabilities, and secretion of proinflammatory molecules, ROS, and RNS.(101) A study using bone marrow chimeric rats has shown that microglia are respo”