Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.

By K. Lauber, E. Bohn, S. Kröber, Yi-jin Xiao, S. Blumenthal, Ralph Lindemann, P. Marini, C. Wiedig, A. Zobywalski, S. Baksh and 6 more. Cell, 2003

987 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/5b698cd57bd398edeaa84f2b6b577187281ffc05

How researchers see this paper

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In Immunology

1. Guido Kroemer
2. L. Galluzzi
3. Oliver Soehnlein
4. M. Perretti
5. A. Ortega-Gómez
6. Beth Levine
7. T. Vanden Berghe
8. Seamus J. Martin

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. Beth Levine
4. Peter Vandenabeele
5. Craig B. Thompson
6. T. Vanden Berghe
7. W. Zong
8. Seamus J. Martin

In Physiology

1. Guido Kroemer
2. L. Galluzzi
3. Beth Levine
4. Craig B. Thompson
5. V. Schirrmacher
6. I. Slaninová
7. D. Hanahan
8. R. Weinberg

Citations in the corpus

• Autophagy gene-dependent clearance of apoptotic cells during embryonic development. (2007, background): “Autophagy Gene-Deficient EBs Secrete Lower Levels of the ‘‘Come-Get-Me’’ Signal, Lysophosphatidylcholine The release of lysophosphatidylcholine (LPC) from apoptotic cells functions as a critical come-get-me signal and chemoattractant for phagocyte recruitment (Lauber et al., 2003).”
• Apoptosis: controlled demolition at the cellular level (2008, background): “In this context, lysophosphatidylcholine appears to be generated through the hydrolysis of membrane phosphatidylcholine by an active form of iPLA2 (Ca 2+ -independent phospholipase-A2) that is generated through caspase-3-mediated cleavag”
• Resolution of inflammation: an integrated view (2013, positive): “To date, four major find me signals have been described: lysophosphatidyl-choline (LPC), sphingosine 1-phosphate (S1P), fractalkine (CX 3 CL1), and the nucleotides ATP and UTP (Elliott et 2009; Gude et al, 2008; Lauber et al, 2003; Truman et al, 2008).”
• Apoptotic cells promote their own clearance and immune tolerance through activation of LXR (2009, neutral): “In contrast to other types of phagocytosis, such as bacterial or necrotic cell uptake, scavenging of apoptotic cells is immunologically silent (Lauber et al., 2004).”
• Necrotic death as a cell fate. (2006, background): “These dying cells release chemoattractant molecules such as lysophosphatidylcholine (LPC) (Lauber et al. 2003), and display the “eat-me” signals such as phophatidylserine (PS) on the cell surface to ensure the efficient removal of apoptotic cells (Fadok et al.”
• The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. (2020, background): “LysoPC, also known as lysolecithin, recruits phagocytes to the site of apoptosis and facilitates opsonization of apoptotic cells, and increase chondrocyte apoptosis, which is an important characteristic in OA pathogenesis (Hwang and Kim, 2015; Lauber et al., 2003).”