Evidence for a role of developmental genes in the origin of obesity and body fat distribution.

By S. Gesta, M. Blüher, Yuji Yamamoto, A. Norris, J. Berndt, S. Kralisch, J. Boucher, C. Lewis, C. Kahn. Proceedings of the National Academy of Sciences of the United States of America, 2006

630 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/84d45a5cff43aab56128caa14d0830e07db73ae5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. B. Spiegelman
2. E. Rosen
3. S. Kajimura
4. P. Seale
5. Mitchell A. Lazar
6. Haiming Cao
7. C. R. Kahn
8. S. Gesta

In Molecular Biology

1. B. Spiegelman
2. E. Rosen
3. P. Seale
4. S. Kajimura
5. C. R. Kahn
6. S. Gesta
7. Mitchell A. Lazar
8. M. Trujillo

In Physiology

1. B. Spiegelman
2. E. Rosen
3. S. Kajimura
4. P. Seale
5. J. Kirkland
6. Mitchell A. Lazar
7. T. Tchkonia
8. P. Scherer

Citations in the corpus

• Adipose tissue-derived factors: impact on health and disease. (2006, background): “developmental genes that are maintained after differentiation and long-term culture (19, 20).”
• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “has demonstrated that pre-adipocytes isolated from mouse and human subcutaneous WAT expresses developmental genes that are present prior to the development of WAT in a pattern that is maintained throughout adulthood, suggesting a cell-autonomous function (16).”
• Developmental origin of fat: tracking obesity to its source. (2007, neutral): “Similar differences in development gene expression are observed in preadipocytes isolated from different adipose depots of rodents (Gesta et al., 2006) and humans (Tchkonia et al.”
• Beige Adipocytes are a Distinct Type of Thermogenic Fat Cell in Mouse and Human (2012, background): “Importantly, these immortalized clonal lines retain expression of previously reported interscapular depot and inguinal depotenriched genes (Billon and Dani, 2011; Gesta et al., 2006; Seale et al., 2007) (Figure S1C).”
• Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (2010, neutral): “Finally, at the TBX15-WARS2 locus, TBX15 emerges as the strongest candidate based on the cis eQTL data in omental fat, marked depot-specific differences in adipose tissue expression in mice and humans and associations between TBX15 expression in visceral fat and WHR 45 , 46 .”
• Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Other molecular differences between visceral and peripheral fat may also contribute to insulin resistance associated with visceral adiposity (Gesta et al. 2006; Fontana et al. 2007).”
• Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. (2011, background): “Moreover, subcutaneous and visceral WAT express unique gene signatures (17).”
• Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “The expression levels of previously described markers for different adipose depots were investigated (Gesta et al. 2006).”
• Adipose Tissue Heterogeneity: Implication of depot differences in adipose tissue for Obesity Complications (2012, methodology): “SAT) in the expression of developmental genes such as cell differentiation, organogenesis, anteroposterior or dorso-ventral patterning in both mouse and human (Vohl et al. 2004;Gesta et al. 2006;Tchkonia et al. 2007).”
• Mechanisms and Metabolic Implications of Regional Differences among Fat Depots (2013, background): “Other genes that regulate important developmental pathways also vary, including secreted frizzled-related protein 2 (SFRP2), pregnancy-associated plasma protein A-1 (PAPP-A1), transcription factor T-box 15 (TBX15), and engrailed 1 (En-1) (Gesta et al., 2006; Tchkonia et al., 2007).”
• Adipocyte differentiation from the inside out (2006, background): “Even among white adipocytes, cells from different locations can have distinct molecular and physiological propertie”
• Sex differences in human adipose tissues – the biology of pear shape (2012, background): “Inflammatory and developmental genes, some of which are modulated by sex steroid hormones, are prominent among depot- and sexspecific genes [3-5].”
• Beneficial effects of subcutaneous fat transplantation on metabolism. (2008, methodology): “…markers, mRNA levels of the macrophage cell surface marker F4/80, Il6, and Tnf were measured by real-time qRT-PCR as described previously (Gesta et al., 2006). mRNA expression levels of the fat-related genes Fabp4, Pparg, Fas, leptin, adiponectin, resistin, and Rbp4 in endogenous and…”