Adipocyte differentiation from the inside out

By E. Rosen, O. MacDougald. Nature reviews. Molecular cell biology, 2006

2,656 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/a08ee6fffba416eab1f3fe5e9050c0e9b291142e

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Citations in the corpus

Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle (2010, background): “During adipose tissue development, MSCs commit into adipocyte lineage and eventually give rise to preadipocytes, which cannot be distinguished from MSCs by their morphology or gene expression, but have lost potential for differentiation to other cell lineage”
Metabolism Disrupting Chemicals and Metabolic Disorders (2016, positive): “PPARγ and Runx2, often called the master regulators of fat cell differentiation [108] and sirtuins which play important roles in secretion of adipokines including leptin and adiponectin, hepatic glucose metabolism, insulin sensitivity and inflammation [109].”
Regulation of mTORC1 and its impact on gene expression at a glance (2013, background): “…affects these processes by modulating the expression and the activity of peroxisome proliferatoractivated receptor c (PPARc), a nuclear receptor that controls the expression of genes that are required for fatty acid synthesis, uptake and esterification (reviewed by Rosen and MacDougald, 2006).”
Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications (2019, background): “All of these steps are controlled by a network of interacting transcription factors operating to coordinate the expression of many hundreds of proteins responsible for establishing the mature fat cell phenotype (Figure 2) [75,76].”
Endocrine Disrupting Chemicals and Disease Susceptibility (2011, background): “Activation of PPARγ2 in pre-adipocytes induces them to differentiate into adipocytes and PPARγ is required for this process in vitro and in vivo [17, 18].”
Regulation of energy metabolism by long-chain fatty acids. (2014, background): “Whereas PPARc is not found in preadipocytes, it is expressed during the late stage of adipocyte differentiation, and remains abundantly expressed in differentiated adipocytes [171].”
Forming functional fat: a growing understanding of adipocyte differentiation (2011, background): “Terminal differentiation Once preadipocytes have committed to the adipogenesis programme, a transcriptional cascade is activated that induces the expression of metabolic genes and adipokines associated with the adipocyte phenotype, such as fatty acid-binding protein 4 (FABP4; also known as AP”
Developmental origin of fat: tracking obesity to its source. (2007, positive): “Mature adipocytes in WAT and BAT are also marked by the presence of PPARγ2, markers of terminal differentiation (such as Glut4 and fatty-acid synthase), and insulin-regulated glucose uptake and metabolism (Rosen and MacDougald, 2006).”
Accessories to the crime: functions of cells recruited to the tumor microenvironment. (2012, positive): “…local and bone marrow derived—can be recruited and induced to differentiate into myofibroblasts defined in part by expression of alpha smooth muscle actin (aSMA) (Paunescu et al., 2011), or into adipocytes defined by expression of fatty acid binding protein-4 (FABP4) (Rosen and MacDougald, 2006).”
Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules (2016, background): “In contrast, disruption of Wnt signaling leads to adipogenic differentiation of pre-adipocytes and mesenchymal precursors of adipocytes [95].”
TNF-α and adipocyte biology (2007, background): “The transcriptional regulation of adipocyte differentiation has been extensively studied, at least in vitro (for reviews see, [152,153]).”