Adipose Tissue Heterogeneity: Implication of depot differences in adipose tissue for Obesity Complications

By Mi-Jeong Lee, Yuanyuan Wu, S. Fried. Molecular Aspects of Medicine, 2012

770 citations recorded by the source corpus.

Obesity, defined as excess fat mass, increases risks for multiple metabolic diseases, such as type 2 diabetes, cardiovascular disease and several types of cancer. Over and above fat mass per se, the pattern of fat distribution, android or truncal as compared to gynoid or peripheral, has a profound influence on systemic metabolism and hence risk for metabolic diseases. Increases in upper body adipose tissue (visceral and abdominal subcutaneous) confer an independent risk, while the quantity of gluteofemoral adipose tissue is protective. Variations in the capacity of different depots to store and release fatty acids and to produce adipokines are important determinants of fat distribution and its metabolic consequences. Depot differences in cellular composition and physiology, including innervation and blood flow, likely influence their phenotypic properties. A number of lines of evidence also support the idea that adipocytes from different anatomical depots are intrinsically different as a result of genetic or developmental events. In this chapter, we will review the phenotypic characteristics of different adipose depots and mechanisms that link their depot-specific biology to metabolic complications in men and women.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/450feaa9c0e8c4bc304a7c9ec1c7e2eecc1df787

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. E. Rosen
2. B. Spiegelman
3. S. Grundy

In Epidemiology

1. B. Spiegelman
2. E. Rosen
3. S. Grundy
4. G. Hotamışlıgil
5. Haiming Cao
6. Richard J. Johnson
7. Y. Sautin

In Physiology

1. B. Spiegelman
2. E. Rosen
3. S. Grundy
4. G. Hotamışlıgil
5. Haiming Cao
6. P. Seale
7. S. Kajimura
8. R. Scarpulla

Citations in the corpus

• Metabolic syndrome update. (2016, background): “[14] Lee MJ, Wu Y, Fried SK.”
• What We Talk About When We Talk About Fat (2014, positive): “The most common classification scheme distinguishes between subcutaneous and visceral fat, in large part because the latter depot has a well-known association with metabolic disease, whereas the former does not (or may even be inversely correlated with disease risk) (Lee et al., 2013).”