Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease

By A. Chait, Laura J. den Hartigh. Frontiers in Cardiovascular Medicine, 2020

1,195 citations recorded by the source corpus.

Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date several types of adipose tissue have been identified, namely white, brown, and beige, that reside in various specific anatomical locations throughout the body. The cellular composition, secretome, and location of these adipose depots define their function in health and metabolic disease. In obesity, adipose tissue becomes dysfunctional, promoting a pro-inflammatory, hyperlipidemic and insulin resistant environment that contributes to type 2 diabetes mellitus (T2DM). Concurrently, similar features that result from adipose tissue dysfunction also promote cardiovascular disease (CVD) by mechanisms that can be augmented by T2DM. The mechanisms by which dysfunctional adipose tissue simultaneously promote T2DM and CVD, focusing on adipose tissue depot-specific adipokines, inflammatory profiles, and metabolism, will be the focus of this review. The impact that various T2DM and CVD treatment strategies have on adipose tissue function and body weight also will be discussed.

Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/9dbf14ab17609f205ced718ccf19341bca23f706

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Djillali Annane

In Epidemiology

1. Alexander Sakers
2. José Fernández-Real
3. C. Richard
4. Mirian Krystel De Siqueira
5. Djillali Annane
6. P. Seale
7. X. Monnet
8. Claudio J. Villanueva

In Physiology

1. Alexander Sakers
2. Mirian Krystel De Siqueira
3. P. Seale
4. Claudio J. Villanueva

Citations in the corpus

• Definition and diagnostic criteria of clinical obesity (2025, positive): “95 Consequently, obesity functions as a chronically inflamed state that originates from adipose tissue but also occurs systemically.”
• Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study (2020, background): “More severe COVID-19 in obese patients may be explained by impairments in the adaptive immune response [31], cardiometabolic and thrombotic derangements [32], and alterations in lung function [33].”
• Adipose tissue plasticity in health and disease (2022, background): “…(subcutaneous/ peripheral) obesity by the French physician Jean Vague in the 1950s, studies have shown that increased visceral/central adiposity correlates with worse insulin resistance and an increased risk of cardiometabolic disease, even in normal-weight subjects (Chait and den Hartigh, 2020).”