Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.

By P. Seale, Heather M. Conroe, J. Estall, S. Kajimura, A. Frontini, Jeff Ishibashi, P. Cohen, S. Cinti, B. Spiegelman. Journal of Clinical Investigation, 2011

1,192 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/276ca7bb4c088fc1a548d435c3ff52260aa735c5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. B. Spiegelman
2. S. Kajimura
3. P. Seale
4. Gerald I. Shulman
5. H. Ohno
6. Jun Wu
7. Kosaku Shinoda
8. E. Rosen

In Physiology

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. Jun Wu
5. P. Cohen
6. H. Ohno
7. Gerald I. Shulman
8. Kosaku Shinoda

In Rehabilitation

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. H. Ohno
5. Gerald I. Shulman
6. Kosaku Shinoda
7. L. Sidossis

Citations in the corpus

• FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise (2012, background): “Taken that formation of “beige/brite fat” has been shown to exert anti-obesity, anti-diabetic effects in murine models [11] as well as humans [12], irisin administration has been proposed to be a potentially attractive future therapeutic target for metabolic disorders.”
• Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells (2012, background): “Indeed, it has been shown that PRDM16 expression in primary and immortalized white adipocytes is sufficient to activate a large array of brown-fat selective genes via interacting with several transcriptional factors such as PPARc and PGC1a [26,32,44].”
• Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “Second, even though PRD1-BF-RIZ1 homologous domain-containing protein-16 (PRDM16) has been recognized as a critical transcriptional coactivator for both brown and beige adipocytes, PRDM16 depletion impedes beige adipocyte development upon β-adrenergic stimulation but has no effect on brown adipocyte”
• Different metabolic responses of human brown adipose tissue to activation by cold and insulin. (2011, result): “That the presence of insulin-sensitive BATwould be beneficial for whole-body metabolism is supported by results from studies on genetically modified mice having increased amounts of BAT (Cederberg et al., 2001; Seale et al., 2011).”
• Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling (2014, background): “In several rodent models, browning of WAT depots appears to be protective against diet-induced metabolic disorders, including obesity and diabetes (10,11).”
• Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. (2012, neutral): “Treatment with ANP over a range of concentrations from 1–100 nM, as shown in Figure 3, was able to significantly increase the transcripts for these genes as well as PRDM16 ; the latter is noted to be a significant factor in brown adipogenesis (41).”
• Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “The potential role of this molecule in modulating beige fat cell function was investigated in the fat-specific PRDM16 transgenic mouse model (Seale et al. 2011).”
• Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “For example, fat-selective expression of PRDM16 in obese transgenic mice causes a modest but significant decrease in total adipose mass, accompanied by a small improvement in insulin resistance (Seale et al., 2011).”
• FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. (2012, background): “adipose tissue, but is rather seldom observed in epididymal/perigonadal adipose tissue (Seale et al. 2011).”
• PPAR agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein (2012, neutral): “Antibodies for PRDM16 (Seale et al., 2011), ubiquitin (Santa Cruz), UCP1 (Abcam), β-actin, M2 flag (Sigma) or Pol-II (Cell Signaling) were used for Western blotting.”