Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
By I. Heid, A. Jackson, J. Randall, T. Winkler, L. Qi, V. Steinthorsdottir, G. Thorleifsson, M. Zillikens, Elizabeth K. Speliotes, Reedik Mägi and 290 more. Nature Genetics, 2010
973 citations recorded by the source corpus.
Subfields: Cancer Research
View Paper: https://www.semanticscholar.org/paper/d67f9b96fd3e4fc0043eb1a4db9901b02c3e5016
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In Cancer Research
Citations in the corpus
- Sex differences in human adipose tissues – the biology of pear shape (2012, background): “GWAS and meta-analyses of GWAS have also identified novel loci associated with central or peripheral fat distribution, some of which are sex-specific (summarized in Table 1) [54,55].”
- A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease (2015, neutral): “The ten newly identified CAD-associated loci were scanned for associations with heritable risk factors for CAD using publically available resources, including large-scale GWAS consortium data downloads 37–41 , 71– Annotation and ENCODE analysis.”
- SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome (2011, neutral): “Although SNPs in SIRT3 have not been identified in large-scale genome-wide association studies in obesity (Heid et al., 2010; Lindgren et al., 2009; Speliotes et al., 2010), diabetes (Dupuis et al., 2010; Prokopenko et al., 2009), or cholesterol and lipid metabolism (Musunuru et al., 2010;…”
- Development and Evaluation of a Genetic Risk Score for Obesity (2013, positive): “However, emerging evidence for gene-sex interactions in obesity (Benjamin et al. 2011; Heid et al. 2010) suggests that future obesity GRSs may require sex-specific construction.”
- Meta-analysis methods for genome-wide association studies and beyond (2013, background): “Finally, sex differences may induce heterogeneity, and some studies suggest differential genetic effects with respect to sex for many common variants 72 , although this has not been borne out in other large-scale empirical studies 73 .”
- Five years of GWAS discovery. (2012, background): “Signals influencing BMI appear to be enriched for genes implicated in neuronal processes, whereas those influencing fat distribution seem to be more closely related to adipose development.(36,43) Overlap with signals and genes implicated inmore severe forms of disease (morbid obesity,”
- A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue (2013, positive): “Indeed, increased levels of DNA methylation were observed after exercise both in the promoter region and in the gene body of ITPR2, a locus previously associated with waist-hip ratio [44].”