The forkhead transcription factor Foxo1 regulates adipocyte differentiation.

By J. Nakae, T. Kitamura, Y. Kitamura, W. Biggs, K. Arden, D. Accili. Developmental Cell, 2003

747 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8260ac2905d3b6156e8f131fafb8ed4f087736cd

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In Cell Biology

1. David M. Sabatini
2. Roberto Zoncu
3. N. Hay
4. Dervis A M Salih
5. A. Brunet
6. T. Mak
7. N. Divecha
8. Michael N. Hall

In Molecular Biology

1. David M. Sabatini
2. W. Gu
3. Roberto Zoncu
4. L. Guarente
5. D. Accili
6. A. Brunet
7. F. Picard
8. A. Efeyan

Citations in the corpus

• Mammalian SIRT1 represses forkhead transcription factors. (2004, methodology): “Canada, K1H 1C4 1993; Kimura et al., 1997 ).”
• FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. (2005, methodology): “Chromatin immunoprecipitation assays We performed ChIP assay in hepatocytes or βTC-3 cells following previously described methods (Nakae et al., 2003).”
• Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. (2003, background): “Akt3 is expressed at the lowest level in most adult tissues except testes and brain (Brodbeck et al. 1999; Nakatani et al. 1999).”
• FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. (2004, neutral): “Alterations of from cultured cells and genetically modified mice indimuscle mass in wasting syndromes, including muscular cates that FoxOs integrate extracellular cues with the atrophy, are invariably accompanied by the induction transcriptional cascade that controls differentiation of of two ubiqui”
• Programmed cell senescence during mammalian embryonic development. (2013, positive): “, 2013; Kuilman and Peeper, 2009) and its well-established capacity to activate the transcription of the p21 gene through SMAD complexes (Datto et al., 1995; Nakae et al., 2003; Reynisdóttir et al., 1995).”
• mTOR: from growth signal integration to cancer, diabetes and ageing (2010, background): “105 ) and to directly inhibit FOXO1, which usually antagonizes PPARγ activit”
• Pancreatic β-Cell Dedifferentiation As Mechanism Of Diabetic β-Cell Failure (2012, positive): “FoxO1 has been found to determine cell fate in differentiating adipocytes (Nakae et al., 2003), myoblasts (Kitamura et al.”
• Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ (2004, background): “Insulin/insulin-like growth factor (IGF)-1 signalling helps to regulate adipogenesi”
• Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. (2004, background): “PKB/Akt directly phosphorylates and inactivates Foxo1, and constitutively active Foxo1 inhibits the induction of PPARγ expression and adipocyte differentiation (32).”
• The role of FoxO in the regulation of metabolism (2008, background): “…a non-phosphorylatable, constitutively active FoxO1 increases expression of p21 and suppresses adipogenesis, whereas a dominantinhibitory FoxO1 not only promotes adipocyte differentiation but also rescues the impaired differentiation in insulin receptor haploinsufficient cells (Nakae et al., 2003).”