FoxOs at the crossroads of cellular metabolism, differentiation, and transformation.

By D. Accili, K. Arden. Cell, 2004

1,390 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b50e94f0e7497c8350680327b4ac997673846e33

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. M. Haigis
2. D. Sinclair
3. Douglas C. Wallace
4. L. Guarente
5. S. Manolagas
6. A. Brunet
7. R. Shaw
8. W. Gu

In Geriatrics and Gerontology

1. D. Sinclair
2. L. Guarente
3. M. Haigis
4. Douglas C. Wallace
5. W. Gu
6. S. Manolagas
7. R. Shaw
8. J. Massagué

In Molecular Biology

1. R. Shaw
2. M. Haigis
3. L. Guarente
4. Gerald I. Shulman
5. A. Brunet
6. David M. Sabatini
7. W. Gu
8. Steven P. Gygi

Citations in the corpus

• The role of FoxO in the regulation of metabolism (2008, background): “Not only is FoxO1 inactivated by Akt phosphorylation, its activity and expression are tightly controlled by the acetylation/deacetylation state (Accili and Arden, 2004).”
• G1 cell-cycle control and cancer (2004, background): “FOXO transcription factors (FOXO-1, -3, -4 and -6) are members of the Forkhead family that constitute a major regulatory node in the control of cell and organismal growth, development, metabolism and longevity under caloric restrictio”
• Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis (2006, background): “When unphosphorylated, FOXO3A functions as a selective transcription factor in the nucleus, inducing the transcription of the genes that encode p27, the cell-cycle-inhibitor cyclin G2 and the pro-apoptotic molecule BI”
• The logic of TGFβ signaling (2006, background): “to their eviction from the nucleus and, in some cases, to their proteosome-mediated degradation [50].”
• A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (2006, positive): “Since the FOXO transcription factors influence cell metabolism, differentiation, and transformation (Accili and Arden, 2004), our findings also raise the possibility that MST might play important roles in these fundamental biological processes.”
• A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine (2005, background): “acetylation via Cbp or p300 (1) and reactivated by deacetylation via the NAD+-dependent”
• Ras, PI(3)K and mTOR signalling controls tumour cell growth (2006, background): “Conversely, FOXO proteins are activated under stress conditions, accumulating in the nucleus and driving the expression of pro-apoptotic genes as well as stress-response genes, such as superoxide dismutase ( SOD2 ), that contribute to lifespan extension in lower metazoan”
• Homozygosity for the patatin‐like phospholipase‐3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease (2010, methodology): “In patients with and without NAFLD, we evaluated the PNPLA3/adiponutrin mRNA levels, and we correlated the PNPLA3 I148M genotype with the expression of insulin receptor (INSR), which regulates insulin signaling and is downregulated in the metabolic syndrome,(27) steroid regulatory element binding pr”
• SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction (2007, background): “FOXO factors regulate metabolism and confer stress resistance (Burgering & Kops, 2002; Accili & Arden, 2004).”
• SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “Moreover, when Per2 binds to the CLOCK-BMAL1 complex, it is also acetylated (2).”
• Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis. (2007, background): “assays in response to progesterone and cAMP (39).”
• Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. (2008, neutral): “FOXO proteins are also important in many of the biological effects of insulin in mammals (Accili and Arden, 2004; van der Horst and Burgering, 2007).”
• FoxO3 regulates neural stem cell homeostasis (2009, positive): “, Pdk1, Slc2a3) (Figures 7A and 7C; Figure S7), consistent with the known role of the FoxO family in stress resistance and cellular metabolism (Accili and Arden, 2004).”
• Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. (2005, background): “AKT inhibitor, phosphatase and tensin analog, is lost (42).”
• Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction (2006, background): “Increased gluconeogenesis further exacerbates hepatic insulin resistance and results in fasting hyperglycemia (43,75,76).”
• FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. (2005, background): “Because of their pivotal role in diverse cellular processes, there exist complex mechanisms to regulate FoxOdependent transcription (Accili and Arden, 2004).”