The role of FoxO in the regulation of metabolism

By David H. Gross, A. V. D. Heuvel, M. Birnbaum. Oncogene, 2008

647 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/98f2631ea746ed9c7ba6e64a7104390d15ddf9b7

How researchers see this paper

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In Molecular Biology

1. J. Goldstein
2. Michael S. Brown
3. Johan Auwerx
4. B. Manning
5. C. Cantó
6. J. Zierath
7. Shijie Li
8. Douglas C. Wallace

In Physiology

1. Johan Auwerx
2. C. Cantó
3. Joseph A. Baur
4. B. Manning
5. J. Zierath
6. Sander M. Houten
7. Douglas C. Wallace
8. G. Hotamışlıgil

In Surgery

1. J. Goldstein
2. Michael S. Brown
3. B. Manning
4. C. Cantó
5. J. Zierath
6. Johan Auwerx
7. Douglas C. Wallace
8. G. Hotamışlıgil

Citations in the corpus

• Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. (2008, background): “…of skeletal muscle fibers, as the metabolic actions of these transcriptional regulators are stimulated by SIRT1-mediated deacetylation, leading to the promotion of oxidative muscle function (Frescas et al., 2005; Gross et al., 2008; Handschin et al., 2007; Lin et al., 2002; Rodgers et al., 2008).”
• Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways (2011, background): “FOXO1 stimulates gluconeogenic gene expression in the liver and is directly phosphorylated and inhibited by Akt (Gross et al., 2009).”
• Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle (2010, background): “…are achieved through the modulation of transcriptional regulators, such as the coactivator PGC-1a or the FOXO family of transcription factors, both of which are intimately linked to the regulation of mitochondrial and fatty acid metabolism (Gross et al., 2008; Handschin Ce and Spiegelman, 2006).”
• Foxp3 reprograms T cell metabolism to function in low glucose high lactate environments (2017, background): “Foxo1 is well described to suppress glycolysis and increase lipid oxidation (Gross et al., 2008).”
• Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis (2010, background): “Inhibitor studies in cultured cells, and gene knockout experiments in mice, have shown that this pathway is required both for inhibition of FoxO1 activity (13, 14) and for induction of SREBP-1c expression (15–17).”