Mammalian SIRT1 represses forkhead transcription factors.

By Maria Carla Motta, N. Divecha, M. Lemieux, C. Kamel, Delin Chen, W. Gu, Yvette Bultsma, M. McBurney, L. Guarente. Cell, 2004

1,448 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1979ae04fc3f4411b46f6a90b953807ebe444584

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Citations in the corpus

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells (2005, neutral): “Also, gluconeogenesis in the liver is regulated by Sirt1 [19], which works in concert with the transcriptional co-activator, peroxisome proliferator-activated receptor coactivator, PGC-1a [21].”
The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control (2008, neutral): “In addition, a number of nonhistone proteins, including p53 (Luo et al., 2001; Vaziri et al., 2001), FOXO3 (Brunet et al., 2004; Motta et al., 2004), PGC-1a (Nemoto et al., 2005; Rodgers et al., 2005), and LXR (Li et al., 2007a), are regulated by SIRT1-mediated deacetylation, stressing the pivotal f”
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase (2004, background): “Consistent with the finding that SIRT1 modulates p300-mediated transcription, during the preparation of this article, a paper was published demonstrat- ing that SIRT1 inhibited p300 activity, which was required for forkhead-mediated transcription and cell death (Motta et al, 2004).”
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. (2008, neutral): “SIRT1 was found to deacetylate not only histones but also several transcriptional regulatory proteins involved in the control of metabolism, including members of the FOXO protein family (Bordone et al., 2006; Brunet et al., 2004; Motta et al., 2004), peroxisome proliferator-activated receptor gamma ”
Regulation of SIRT1 and Its Roles in Inflammation (2022, background): “On the other hand, FOXO3a can be deacetylated by SIRT1, an interaction which enables the FOXO family to participate in the regulation of various biological processes such as the cell cycle, energy metabolism, and oxidative stress (42, 43).”
FOXO transcription factors at the interface between longevity and tumor suppression (2005, background): “SIRT1 directly catalyses the deacetylation of FOXO factors in vitro and participates in the deacetylation of these factors within cells (Brunet et al., 2004; Daitoku et al., 2004; Motta et al., 2004; Van Der Horst et al., 2004; Frescas et al., 2005; Yang et al., 2005b).”
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine (2005, background): “Further, caloric restriction reduces cellular NADH/NAD+ ratios, activating the NAD+dependent SIRT1, which further activates the FOXOs by deacetylation (24, 61, 155).”
FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. (2011, background): “The role of sirtuins and FoxO deacetylation in FoxO function, however, is also controversial, with results suggesting both negative and positive effects [121– 123,125,126].”
Redox regulation of FoxO transcription factors (2015, methodology): “Acetylation has been shown to result in both stimulation and inhibition of the transcriptional activity of FoxOs, depending on the examined FoxO isoforms and their binding partners such as other transcription factors and transcriptional co-activators, the FoxO target genes and the cell types used in”