Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

By F. Picard, Martin V. Kurtev, Namjin Chung, A. Topark-ngarm, T. Senawong, R. M. Oliveira, M. Leid, M. McBurney, L. Guarente. Nature, 2004

2,044 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/ebcbc3a3de8c301871b90e444ae3fbfdaf1e244e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

In Geriatrics and Gerontology

In Physiology

Citations in the corpus

Resveratrol improves health and survival of mice on a high-calorie diet (2006, neutral): “11) Fed Citrate synthase (liver, AU mg(21)) 141 (14) 128 (21) 138 (11) Fed Body temperature (uC) 34.”
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ (2012, positive): “The inhibitory effect of SirT1 on these white genes is consistent with its lipid mobilizing function in white adipocyte (Picard et al., 2004).”
Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice (2006, background): “Soy isoflavones exert antidiabetic and hypolipidemic effects through PPAR pathways in obese Zucker rats and murine RAW 264.7 cells (44).”
Therapeutic potential of NAD-boosting molecules: the in vivo evidence (2018, positive): “SIRT1 and its downstream targets PGC-1a, PSK9, and SREBP1 maintain mitochondrial function, cholesterol transport, and fatty acid homeostasis (Baur et al., 2006; Picard et al., 2004; Rodgers et al., 2005; Yang et al., 2006).”
Sirt1 and the Mitochondria (2016, background): “Sirt1 represses a key metabolic regulator, Peroxisome Proliferator-Activated Receptor gamma (PPARγ) (Picard et al., 2004; Sugden et al., 2010), via deacetylation of PPARγ coactivator-1α (PGC-1α) (Gerhart-Hines et al., 2007; Lagouge et al., 2006; Nemoto et al., 2005; Rodgers et al., 2005), which…”
DNA damage-induced alterations in chromatin contribute to genomic integrity and age-related changes in gene expression (2008, positive): “The mammalian ortholog of Sir2, SIRT1, regulates both the expression of individual genes (Picard et al., 2004; Pruitt et al., 2006; Vaquero et al., 2004) and the formation of facultative heterochromatin (Vaquero et al.”
The role of FoxO in the regulation of metabolism (2008, background): “Sirt1, another sirtuin family member expressed in adipocytes, can also prevent adipocyte differentiation (Picard et al., 2004; Bai et al., 2007).”