Pharmacokinetics and Bioavailability of Quercetin Glycosides in Humans

By E. Graefe, Joerg Wittig, Silke C Mueller, A. Riethling, Bernhard Uehleke, B. Drewelow, H. Pforte, G. Jacobasch, H. Derendorf, M. Veit. Journal of clinical pharmacology, 2001

634 citations recorded by the source corpus.

Subfields: Biochemistry, Endocrinology, Diabetes and Metabolism, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/7b036a019c1f4aee1af703a6d534f0713f5968c4

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Citations in the corpus

Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology (2004, background): “Interindividual variation in bioavailability Several studies indicate marked individual variation in the bioavailability of flavonoids [104,105,113].”
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease (2019, background): “Because senescent cells can takeweeks tomonths to develop and do not divide, and because even eliminating only 30% of senescent cells can be sufficient to alleviate dysfunction in preclinical studies [3,5,7,9,23,24,28,32–37], D+Q is as effective inmice if administered intermittently, for example eve”
Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid (2016, background): “[56,58] Quercetin with its radical scavenging potential is said to be capable of preventing cancer which is induced by oxidative stress.”
Polyphenols, dietary sources and bioavailability. (2007, background): “4% of the ingested dose of quercetin and its glycosides [83, 100, 131].”
Polyphenols: food sources and bioavailability. (2004, background): “75 mol/L after consumption of 80–100 mg quercetin equivalent administered in the form of apples, onions, or meals rich in plant products (90, 92, 107).”
Flavonoid Bioavailability and Attempts for Bioavailability Enhancement (2013, background): “Flavonols Sugars and their position affects bioavailability [44].”
A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. (2007, background): “…was not identified in plasma samples following oral administration of the flavonol (Manach et al., 1998; Erlund et al., 2000; Walle et al., 2000; Graefe et al., 2001), more recent trials utilizing improved detection methods have demonstrated trace quantities of the aglycone in the plasma of one…”
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. (2005, background): “Generally, 20–40% of quercetin is methylated in the 3'-position, yielding isorhamnetin (31, 34, 38).”