Flavonoid Bioavailability and Attempts for Bioavailability Enhancement
By S. Thilakarathna, H. Rupasinghe. Nutrients, 2013
711 citations recorded by the source corpus.
Flavonoids are a group of phytochemicals that have shown numerous health effects and have therefore been studied extensively. Of the six common food flavonoid classes, flavonols are distributed ubiquitously among different plant foods whereas appreciable amounts of isoflavones are found in leguminous plant-based foods. Flavonoids have shown promising health promoting effects in human cell culture, experimental animal and human clinical studies. They have shown antioxidant, hypocholesterolemic, anti-inflammatory effects as well as ability to modulate cell signaling and gene expression related disease development. Low bioavailability of flavonoids has been a concern as it can limit or even hinder their health effects. Therefore, attempts to improve their bioavailability in order to improve the efficacy of flavonoids are being studied. Further investigations on bioavailability are warranted as it is a determining factor for flavonoid biological activity.
Subfields: Biochemistry, Endocrinology, Diabetes and Metabolism, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/635af47f33a89f5ef633fcf161d94658cc483c43
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Citations in the corpus
- Important Flavonoids and Their Role as a Therapeutic Agent (2020, background): “The presence of bioactive phytochemical constituents present in these different plants parts gives them their medicinal value and biological activities [4].”
- Flavonoids in Cancer and Apoptosis (2018, background): “Several research groups are attempting to enhance the bioavailability of protective flavonoid compounds by improving intestinal absorption, altering the site of absorption and improving metabolic stability [250].”
- Natural antioxidants as stabilizers for polymers (2017, background): “A limiting factor of medical applications is the poor bioavailability of flavonoids [84,85].”
- Flavonoids as Potential Anti-Inflammatory Molecules: A Review (2022, background): “The absorption and bioavailability of flavonoids differ by their structure, molecular weight, and their ability to undergo esterification glycosylation [27].”