Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.

By M. Gavin, T. Torgerson, Evan G. Houston, Paul C. Deroos, W. Ho, A. Stray-Pedersen, E. Ocheltree, P. Greenberg, H. Ochs, Alexander Y. Rudensky. Proceedings of the National Academy of Sciences of the United States of America, 2006

841 citations recorded by the source corpus.

Subfields: Education, Immunology

View Paper: https://www.semanticscholar.org/paper/74fcb71c02005df3c0921e5a7f617e9ff7948e04

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In Immunology

Citations in the corpus

Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. (2007, background): “In human T cells, it is known that Foxp3 upregulation does not necessarily connote stable commitment to Treg differentiation (37, 38), so it is possible that not all of the newly derived Foxp3+ cells would go on to become Tregs.”
Regulatory T cells and immune tolerance. (2008, background): “In addition, unlike mice, naive T cells in humans readily express Foxp3 upon TCR stimulation, although the expression is generally much lower and more transient than in natural Tregs (Yagi et al., 2004; Gavin et al., 2006).”
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. (2009, background): “For example, it has been reported that mere TCR stimulation can induce FoxP3 expression in apparently naive human FoxP3 CD4 T cells without conferring suppressive activity (Allan et al., 2007; Gavin et al., 2006; Tran et al., 2007; Wang et al., 2007).”
FOXP3+ regulatory T cells in the human immune system (2010, background): “However, it was then shown that both CD25 and FOXP3 expression could be induced in human naive CD4 + T cells through cell activation, obscuring the identification of FOXP3 + T cells as pure T Reg cell”
Control of regulatory T cell lineage commitment and maintenance (2009, background): “However, Foxp3 protein itself appears to be required for the heritable maintenance of Foxp3 expression, but does not augment the expression level of Foxp3 on a per cell basis, suggesting existence of a feed-forward regulatory loop (Figure 2; Gavin et al., 2007).”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “Additionally, this FOXP3 expression in conventional human T cells in the presence of high amounts of TGF-β does not confer suppressor function (189, 192).”
Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. (2007, background): “Consequently, simple analysis of FOXP3 expression can no longer be used as a surrogate marker of nTregs in humans ( 12 , 20, 21).”
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. (2012, background): “However, Foxp3 expression may not always specify Treg cells; in humans, activated T cells transiently upregulate FOXP3 without acquiring a Treg cell phenotype and function (Allan et al., 2007; Gavin et al., 2006; Tran et al., 2007; Wang et al., 2007; Ziegler, 2006), although such ‘‘promiscuous’’ Fox”
Epigenetic Control of the foxp3 Locus in Regulatory T Cells (2007, neutral): “function, especially in the human system [28,29].”
Foxp3 in control of the regulatory T cell lineage (2007, background): “Only some human T cells upregulate Foxp3 upon activation; this upregulation is transient and involves significantly lower quantities of Foxp3 than those observed in human T reg cell”